SATB1 (Ser47) Antibody

• Catalog number
  bs-3390R
• Price
  Please ask
• Size
  0.1ml

• Long name
  SATB1 (Ser47) Primary Polyclonal Antibody
• Also known as
  SATB1 (Ser47) PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  SATB1 Ser47
• Specificity
  This is a highly specific antibody against SATB1 Ser47.
• Modification s
  Phosphorylation
• Modification site s
  Ser47
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  21-71/763
• Subcellular location
  Nucleus
• Source
  KLH conjugated synthetic phosphopeptide derived from human SATB1 around the phosphorylation site of Ser47
• Gene ID number
  6304
• Swiss Prot
  Q01826
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  DNA-binding protein SATB1; Special AT-rich sequence-binding protein 1; SATB1
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  SATB1   Ser47  
• Gene symbol
  SATB1, SATB1-AS1
• Short name
  Anti-SATB1 Ser47
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  SATB1 (Ser47) Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  SATB homeobox 1, SATB1 and IDBG-21555 and ENSG00000182568 and 6304, sequence-specific DNA binding, nuclei, Satb1 and IDBG-190608 and ENSMUSG00000023927 and 20230, SATB1 and IDBG-640809 and ENSBTAG00000021158 and 516952

Gene info

• Identity
  HGNC:10541
• Gene
  SATB1
• Long gene name
  SATB homeobox 1
• Synonyms gene name
  • special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA)
• Locus
  3p24.3
• Discovery year
  1994-05-03
• Entrez gene record
  6304
• Pubmed identfication
  • 1505028
• RefSeq identity
  • NM_001131010
• Classification
  • CUT class homeoboxes and pseudogenes
• VEGA ID
  OTTHUMG00000129890

Gene info

• Identity
  HGNC:50687
• Gene
  SATB1-AS1
• Long gene name
  SATB1 antisense RNA 1
• GenBank acession
  • DR006704
• Locus
  3p24.3
• Discovery year
  2014-06-05
• Entrez gene record
  101927777
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000155346

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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