SATB1 (Ser47) Antibody, Cy3 Conjugated

• Catalog number
  bs-3390R-Cy3
• Price
  Please ask
• Size
  0.1ml

• Long name
  SATB1 (Ser47) Polyclonal Antibody, Cy3 Conjugated
• Category
  Conjugated Primary Antibodies
• Conjugation
  Cy3
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  SATB1 Ser47
• Specificity
  This is a highly specific antibody against SATB1 Ser47.
• Modification
  Phosphorylation
• Modification site
  Ser47
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen_range
  21-71/763
• Subcellular location
  Nucleus
• Source
  KLH conjugated synthetic phosphopeptide derived from human SATB1 around the phosphorylation site of Ser47
• Gene ID number
  6304
• Swiss Prot
  Q01826
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse
• Crossreactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Antigen background
  Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
• Excitation Emission
  512,550nm/570,615nm
• Synonyms
  DNA-binding protein SATB1; Special AT-rich sequence-binding protein 1; SATB1
• Properties
  If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser. 1 of the Anti-SATB1 Ser47 can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC. This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy.
• Additional conjugation
  cy3 conjugation kit
• French translation
  anticorps

• Gene target
  SATB1   Ser47   Conjugated  
• Gene symbol
  SATB1, SATB1-AS1
• Short name
  Anti-SATB1 Ser47
• Technique
  Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
• Isotype
  Immunoglobulin G (IgG)
• Label
  Cy3
• Alternative name
  Anti-SATB1 Ser47 PAb Cy3
• Alternative technique
  antibodies
• Alternative to gene target
  SATB homeobox 1, SATB1 and IDBG-21555 and ENSG00000182568 and 6304, sequence-specific DNA binding, nuclei, Satb1 and IDBG-190608 and ENSMUSG00000023927 and 20230, SATB1 and IDBG-640809 and ENSBTAG00000021158 and 516952

Gene info

• Identity
  HGNC:10541
• Gene
  SATB1
• Long gene name
  SATB homeobox 1
• Synonyms gene name
  • special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA)
• Locus
  3p24.3
• Discovery year
  1994-05-03
• Entrez gene record
  6304
• Pubmed identfication
  • 1505028
• RefSeq identity
  • NM_001131010
• Classification
  • CUT class homeoboxes and pseudogenes
• VEGA ID
  OTTHUMG00000129890

Gene info

• Identity
  HGNC:50687
• Gene
  SATB1-AS1
• Long gene name
  SATB1 antisense RNA 1
• GenBank acession
  • DR006704
• Locus
  3p24.3
• Discovery year
  2014-06-05
• Entrez gene record
  101927777
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000155346

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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