RUNX1 (Ser266) Antibody

• Catalog number
  bs-3024R
• Price
  Please ask
• Size
  0.1ml

• Long name
  RUNX1 (Ser266) Primary Polyclonal Antibody
• Also known as
  RUNX1 (Ser266) PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  RUNX1 Ser266
• Specificity
  This is a highly specific antibody against RUNX1 Ser266.
• Modification s
  Phosphorylation
• Modification site s
  Ser266
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  240-280/453
• Subcellular location
  Nucleus
• Source
  KLH conjugated synthetic phosphopeptide derived from human RUNX1 around the phosphorylation site of Ser266
• Gene ID number
  861
• Swiss Prot
  Q01196
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B-dependent transcriptional activation. Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532).
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  AML1; CBFA2; EVI-1; AMLCR1; PEBP2aB; CBF2alpha; AML1-EVI-1; PEBP2alpha; Runt-related transcription factor 1; Acute myeloid leukemia 1 protein; Core-binding factor subunit alpha-2; CBF-alpha-2; Oncogene AML-1; Polyomavirus enhancer-binding protein 2 alpha B subunit; PEA2-alpha B; PEBP2-alpha B; SL3-3 enhancer factor 1 alpha B subunit; SL3/AKV core-binding factor alpha B subunit; RUNX1
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  RUNX1   Ser266  
• Gene symbol
  RUNX1-IT1, RUNX1
• Short name
  Anti-RUNX1 Ser266
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  RUNX1 (Ser266) Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  runt-related transcription factor 1, AML1 and AML1-EVI-1 and AMLCR1 and CBFA2 and EVI-1 and PEBP2aB, RUNX1 and IDBG-2825 and ENSG00000159216 and 100506403,101928269,861, repressing transcription factor binding, nuclei, Runx1 and IDBG-177713 and ENSMUSG00000022952 and 12394, RUNX1 and IDBG-640443 and ENSBTAG00000004742 and 529631

Gene info

• Identity
  HGNC:16623
• Gene
  RUNX1-IT1
• Long gene name
  RUNX1 intronic transcript 1
• Synonyms gene
  • C21orf96
• Synonyms gene name
  • chromosome 21 open reading frame 96
  • RUNX1 intronic transcript 1 (non-protein coding)
• Synonyms
  • FLJ20856
• GenBank acession
  • AK024509
• Locus
  21q22.12
• Discovery year
  2003-10-01
• Entrez gene record
  80215
• Pubmed identfication
  • 32487998
• RefSeq identity
  • NR_026812
• Classification
  • Intronic transcripts

Gene info

• Identity
  HGNC:10471
• Gene
  RUNX1
• Long gene name
  RUNX family transcription factor 1
• Synonyms gene
  • AML1
  • CBFA2
• Synonyms gene name
  • acute myeloid leukemia 1
  • runt-related transcription factor 1
  • runt related transcription factor 1
• Synonyms
  • PEBP2A2
  • AMLCR1
• Synonyms name
  • aml1 oncogene
• GenBank acession
  • X79549
• Locus
  21q22.12
• Discovery year
  1991-08-20
• Entrez gene record
  861
• Pubmed identfication
  • 1427868
  • 7835892
• Classification
  • Runt-related transcription factors
• VEGA ID
  OTTHUMG00000086299
• Locus Specific Databases
  • LRG_482

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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