PINK1 (38CT20.8.5) Monoclonal Antibody

• Catalog number
  bsm-51265M
• Price
  Please ask
• Size
  0.1ml

• Long name
  PINK1 (38CT20.8.5) Monoclonal Antibody
• Also known as
  PINK1 (38CT20.8.5) Monoclonal Antibody
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  PINK1
• Specificity
  This is a highly specific antibody against PINK1.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Monoclonal
• Clone number
  38CT20.8.5
• Source
  Recombinant PINK1 protein was used to produced this monoclonal antibody.
• Gene ID number
  65018
• Swiss Prot
  Q9BXM7
• Tested Applications
  WB, IHC-P, IF
• Recommended dilutions
  WB(1:2000), IHC-P(1:25)
• Cross reactivity
  Human
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2. Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2. Activates PARK2 in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PARK2 and (2) mediating phosphorylation of ubiquitin, converting PARK2 to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291).
• Purification method
  Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  BRPK; PARK6; Serine/threonine-protein kinase PINK1, mitochondrial; PTEN-induced putative kinase protein 1; PINK1
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  PINK1   38CT20   Monoclonal  
• Gene symbol
  PINK1-AS, PINK1
• Short name
  Anti-PINK1
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Isotype
  Immunoglobulin G (IgG)1
• Alternative name
  PINK1 (38CT20.8.5) Monoclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  PTEN induced putative kinase 1, PINK1 and IDBG-92922 and ENSG00000158828 and 65018, transferase activity, nuclei, Pink1 and IDBG-199773 and ENSMUSG00000028756 and 68943, PINK1 and IDBG-645657 and ENSBTAG00000006084 and 510683

Gene info

• Identity
  HGNC:38872
• Gene
  PINK1-AS
• Long gene name
  PINK1 antisense RNA
• Synonyms gene
  • PINK1-AS1
• Synonyms gene name
  • PINK1 antisense RNA 1 (non-protein coding)
  • PINK1 antisense RNA (non-protein coding)
• Synonyms
  • FLJ00387
  • PINK1AS
  • naPINK1
• GenBank acession
  • AK090466
• Locus
  1p36.12
• Discovery year
  2010-08-19
• Pubmed identfication
  • 17362513
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000002840

Gene info

• Identity
  HGNC:14581
• Gene
  PINK1
• Long gene name
  PTEN induced kinase 1
• Synonyms gene
  • PARK6
• Synonyms gene name
  • Parkinson disease (autosomal recessive) 6
  • PTEN induced putative kinase 1
• Synonyms
  • BRPK
• GenBank acession
  • AB053323
• Locus
  1p36.12
• Discovery year
  2001-02-08
• Entrez gene record
  65018
• Pubmed identfication
  • 24751536
  • 11494141
  • 15349860
  • 14607334
• RefSeq identity
  • NM_032409
• Classification
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000002841
• Locus Specific Databases
  • Global Variome shared LOVD

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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