MGLUR1 + MGLUR5 Antibody

• Catalog number
  bs-12014R
• Price
  Please ask
• Size
  0.1ml

• Long name
  MGLUR1 + MGLUR5 Primary Polyclonal Antibody
• Also known as
  MGLUR1 + MGLUR5 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  MGLUR1 + MGLUR5
• Specificity
  This is a highly specific antibody against MGLUR1 + MGLUR5.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MGLUR1 + MGLUR5
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Glutamate is the main excitatory neurotransmitter in the brain. For many years it had been considered to act only on the ligand-gated receptor channels-termed NMDA, AMPA and kainite receptors that are involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate enzymes producing second messengers via specific receptors coupled to G-proteins. These receptors are called metabotropic glutamate receptors. In expression systems, Group-I receptors stimulate phospholipase C as revealed by an increase in phosphoinositide turnover and calcium release from internal stores. Group-II and -III receptors are coupled to the inhibition of adenylyl cyclase. The Group-I receptors include Metabotropic Glutamate Receptor 5 and Metabotropic Glutamate Receptor 1a. The Group-II receptors in include mGluR2 and mGluR3.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  MGLUR1+MGLUR5; GPRC1A; GPRC1E; GRM1; GRM1A; GRM5; Metabotropic glutamate receptor 1; Metabotropic glutamate receptor 5; mGlu1; mGlu5; MGLUR1; MGLUR1A; MGLUR5; MGLUR5B; GRM1_HUMAN; GRM5_HUMAN.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  MGLUR1   MGLUR5  
• Gene symbol
  GRM1, GRM5
• Short name
  Anti-MGLUR1 + MGLUR5
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  MGLUR1 + MGLUR5 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:4593
• Gene
  GRM1
• Long gene name
  glutamate metabotropic receptor 1
• Synonyms gene name
  • glutamate receptor, metabotropic 1
• Synonyms
  • GPRC1A
  • mGlu1
  • MGLUR1
  • PPP1R85
• Synonyms name
  • protein phosphatase 1, regulatory subunit 85
• GenBank acession
  • U31215
• Locus
  6q24.3
• Discovery year
  1993-10-21
• Entrez gene record
  2911
• Pubmed identfication
  • 9076744
  • 9376535
• RefSeq identity
  • NM_000838
• Classification
  • Glutamate metabotropic receptors
  • Protein phosphatase 1 regulatory subunits
• VEGA ID
  OTTHUMG00000015752

Gene info

• Identity
  HGNC:4597
• Gene
  GRM5
• Long gene name
  glutamate metabotropic receptor 5
• Synonyms gene name
  • glutamate receptor, metabotropic 5
• Synonyms
  • MGLUR5
  • GPRC1E
  • mGlu5
  • PPP1R86
• Synonyms name
  • protein phosphatase 1, regulatory subunit 86
• GenBank acession
  • D28538
• Locus
  11q14.2-q14.3
• Discovery year
  1993-10-22
• Entrez gene record
  2915
• Pubmed identfication
  • 7908515
• RefSeq identity
  • NM_000842
• Classification
  • Glutamate metabotropic receptors
  • Protein phosphatase 1 regulatory subunits
• VEGA ID
  OTTHUMG00000134306

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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