MGLUR1 + MGLUR5 Antibody, Cy5 Conjugated
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Catalog numberbs-12014R-Cy5
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Price:
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Size0.1ml
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Long nameMGLUR1 + MGLUR5 Polyclonal Antibody, Cy5 Conjugated
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CategoryConjugated Primary Antibodies
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ConjugationCy5
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Host OrganismRabbit (Oryctolagus cuniculus)
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Target AntigenMGLUR1 + MGLUR5
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SpecificityThis is a highly specific antibody against MGLUR1 + MGLUR5.
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ModificationUnmodified
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Modification siteNone
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ClonalityPolyclonal
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ClonePolyclonal antibody
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Concentration1ug per 1ul
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SourceKLH conjugated synthetic peptide derived from human MGLUR1 + MGLUR5
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Tested applicationsIF(IHC-P)
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Recommended dilutionsIF(IHC-P)(1:50-200)
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CrossreactivityHuman, Mouse, Rat
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Crossreactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Antigen backgroundGlutamate is the main excitatory neurotransmitter in the brain. For many years it had been considered to act only on the ligand-gated receptor channels-termed NMDA, AMPA and kainite receptors that are involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate enzymes producing second messengers via specific receptors coupled to G-proteins. These receptors are called metabotropic glutamate receptors. In expression systems, Group-I receptors stimulate phospholipase C as revealed by an increase in phosphoinositide turnover and calcium release from internal stores. Group-II and -III receptors are coupled to the inhibition of adenylyl cyclase. The Group-I receptors include Metabotropic Glutamate Receptor 5 and Metabotropic Glutamate Receptor 1a. The Group-II receptors in include mGluR2 and mGluR3.
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Purification methodThis antibody was purified via Protein A.
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Storage conditionsKeep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
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Excitation Emission625,650nm/670nm
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SynonymsMGLUR1+MGLUR5; GPRC1A; GPRC1E; GRM1; GRM1A; GRM5; Metabotropic glutamate receptor 1; Metabotropic glutamate receptor 5; mGlu1; mGlu5; MGLUR1; MGLUR1A; MGLUR5; MGLUR5B; GRM1_HUMAN; GRM5_HUMAN.
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PropertiesIf you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor.
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Additional conjugationCy5.5
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French translationanticorps
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Gene target
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Gene symbolGRM1, GRM5
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Short nameAnti-MGLUR1 + MGLUR5
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TechniqueAntibody, antibodies against human proteins, antibodies for, antibody Conjugates
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IsotypeImmunoglobulin G (IgG)
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LabelCy5
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Alternative nameAnti-MGLUR1 + MGLUR5 PAb Cy5
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene nameglutamate metabotropic receptor 1
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Synonyms gene name
- glutamate receptor, metabotropic 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1993-10-21
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Glutamate metabotropic receptors
- Protein phosphatase 1 regulatory subunits
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameglutamate metabotropic receptor 5
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Synonyms gene name
- glutamate receptor, metabotropic 5
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1993-10-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Glutamate metabotropic receptors
- Protein phosphatase 1 regulatory subunits
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data