LRP5 Antibody

• Catalog number
  bs-4117R
• Price
  Please ask
• Size
  0.1ml

• Long name
  LRP5 Primary Polyclonal Antibody
• Also known as
  LRP5 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  LRP5
• Specificity
  This is a highly specific antibody against LRP5. This antibody will recognize LRP6 due to high sequence similarity.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  500-550/1615
• Subcellular location
  Extracellular
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human LRP5
• Gene ID number
  4041
• Swiss Prot
  O75197
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  HBM; LR3; OPS; EVR1; EVR4; LRP7; OPPG; BMND1; LRP-5; OPTA1; VBCH2; Low-density lipoprotein receptor-related protein 5; LRP5
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  LRP5  
• Gene symbol
  LRP5
• Short name
  Anti-LRP5
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  LRP5 Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  low density lipoprotein receptor-related protein 5, BMND1 and EVR1 and EVR4 and HBM and LR3 and LRP-5 and LRP7 and OPPG and OPS and OPTA1 and VBCH2, LRP5 and IDBG-61383 and ENSG00000162337 and 4041, Wnt-activated receptor activity, Plasma membranes, Lrp5 and IDBG-128306 and ENSMUSG00000024913 and 16973, LRP5 and IDBG-644859 and ENSBTAG00000005903 and 534450

Gene info

• Identity
  HGNC:6697
• Gene
  LRP5
• Long gene name
  LDL receptor related protein 5
• Synonyms gene
  • LRP7
  • OPPG
  • EVR1
• Synonyms gene name
  • osteoporosis pseudoglioma syndrome
  • exudative vitreoretinopathy 1
  • low density lipoprotein receptor-related protein 5
• Synonyms
  • LR3
  • BMND1
  • HBM
  • OPS
  • OPTA1
  • VBCH2
  • EVR4
• GenBank acession
  • AF064548
• Locus
  11q13.2
• Discovery year
  1998-04-07
• Entrez gene record
  4041
• Pubmed identfication
  • 9714764
  • 10049586
• RefSeq identity
  • NM_002335
• Classification
  • Low density lipoprotein receptors
• VEGA ID
  OTTHUMG00000167570
• Locus Specific Databases
  • Global Variome shared LOVD

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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