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LRP5 Antibody, ALEXA FLUOR 488

  • Catalog number
    bs-4117R-A488
  • Product name
    LRP5 Antibody, ALEXA FLUOR 488
  • Size
    100ul
  • Short name
    Anti-LRP5
  • Long name
    LRP5 Polyclonal Antibody, ALEXA FLUOR 488 Conjugated
  • Also known as
    Anti-LRP5 PAb ALEXA FLUOR 488
  • Category
    Conjugated Primary Antibodies
  • Conjugated with
    ALEXA FLUOR® 488
  • Host Organism
    Rabbit (Oryctolagus cuniculus)
  • Target Antigen
    LRP5
  • Specificity
    This is a highly specific antibody against LRP5.
  • Modification
    Unmodified
  • Modification Site
    None
  • Clonality
    Polyclonal
  • Clone
    Polyclonal antibody
  • Isotype
    Immunoglobulin G (IgG)
  • Concentration
    1ug per 1ul
  • Immunogen range
    500-550/1615
  • Subcellular location
    Extracellular
  • Source
    This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human LRP5
  • Gene ID Number
    4041
  • Swiss Prot
    O75197
  • Tested applications
    IF(IHC-P)
  • Recommended dilutions
    IF(IHC-P)(1:50-200)
  • Crossreactivity
    Human, Mouse, Rat
  • Cross reactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Background of the antigen
    Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.
  • Purification
    Purified by Protein A.
  • Storage conditions
    Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
  • Excitation emission
    499nm/519nm
  • Synonyms
    HBM; LR3; OPS; EVR1; EVR4; LRP7; OPPG; BMND1; LRP-5; OPTA1; VBCH2; Low-density lipoprotein receptor-related protein 5; LRP5
  • Alternative to gene target
    • [ "low density lipoprotein receptor-related protein 5", "BMND1 and EVR1 and EVR4 and HBM and LR3 and LRP-5 and LRP7 and OPPG and OPS and OPTA1 and VBCH2", "LRP5 and IDBG-61383 and ENSG00000162337 and 4041", "Wnt-activated receptor activity", "Plasma membranes", "Lrp5 and IDBG-128306 and ENSMUSG00000024913 and 16973", "LRP5 and IDBG-644859 and ENSBTAG00000005903 and 534450" ]
  • Gene target
    LRP5
    • Gene info
    Locus Specific Databases:Global Variome shared LOVD
  • Gene symbol
    LRP5
  • isotype filter
    • Immunoglobulin G IgG
  • Label
    ALEXA FLUOR 488
  • label filter
    • ALEXA FLUOR 488
  • technique filter
    • Antibody
  • Technique
    Antibody, antibodies against human proteins, antibodies for
  • Alternative technique
    antibodies