ECT2 Antibody

• Catalog number
  bs-4102R
• Price
  Please ask
• Size
  0.1ml

• Long name
  ECT2 Primary Polyclonal Antibody
• Also known as
  ECT2 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  ECT2
• Specificity
  This is a highly specific antibody against ECT2.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  815-865/914
• Subcellular location
  Cytoplasm, Nucleus
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human ECT2
• Gene ID number
  1894
• Swiss Prot
  Q9H8V3
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  ARHGEF31; Protein ECT2; Epithelial cell-transforming sequence 2 oncogene; ECT2
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  ECT2  
• Gene symbol
  ECT2
• Short name
  Anti-ECT2
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  ECT2 Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  epithelial cell transforming sequence 2 oncogene, ARHGEF31, ECT2 and IDBG-65239 and ENSG00000114346 and 1894, protein homodimerization activity, nuclei, Ect2 and IDBG-134125 and ENSMUSG00000027699 and 13605, BT.28366 and IDBG-636155 and ENSBTAG00000023814 and 100849477,504746

Gene info

• Identity
  HGNC:3155
• Gene
  ECT2
• Long gene name
  epithelial cell transforming 2
• Synonyms gene name
  • epithelial cell transforming sequence 2 oncogene
• Synonyms
  • ARHGEF31
• GenBank acession
  • AA206473
• Locus
  3q26.31
• Discovery year
  1993-10-15
• Entrez gene record
  1894
• Pubmed identfication
  • 8464478
  • 10579713
• RefSeq identity
  • NM_018098
• Classification
  • Dbl family Rho GEFs
• VEGA ID
  OTTHUMG00000156762

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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