DCC Antibody

• Catalog number
  bs-0592R
• Price
  Please ask
• Size
  0.1ml

• Long name
  DCC Primary Polyclonal Antibody
• Also known as
  DCC PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  DCC
• Specificity
  This is a highly specific antibody against DCC.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human DCC
• Gene ID number
  1630
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Deleted in colorectal cancer (DCC, chromosome 18q21) was originally identified as a putative tumor suppressor gene that is lost in more than 70% of colorectal cancers. The gene has also been deleted in several other types of cancer. The DCC protein is a type I transmembrane glycoprotein that belongs to the immunoglobulin (Ig) superfamily. The extracellular domain is composed of four Ig like domains and six fibronectin type III repeats. Native DCC is found in three isoforms. Two forms, a long and a short isoform, are produced from the same gene but have different initiation sites. The third isoform, produced by alternative splicing, is expressed only in embryonic tissue. Mouse DCC extracellular domain shares 97% and 99% homology with human and rat DCC extracellular domains, respectively. In adults, DCC is highly expressed in the brain but is also expressed at very low levels in multiple normal tissues. In the embyro, high levels of expression are detected in the brain and neural tube. DCC functions as a receptor or a component of a receptor for netrins and mediates the effects of netrins on commissural axons. Netrins are chemoattractants responsible for the guidance of commissural axons at the midline and of motor axons to the their target muscles. DCC induces apoptosis in the absence of ligand binding, blocks apoptosis when engaged by netrin 1, and also acts as a caspase substrate.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  Deleted in Colorectal Cancer; Igdcc1; Immunoglobulin domain cell adhesion molecule; Colorectal cancer related chromosome sequence 18; Colorectal cancer suppressor; CRC 18; CRC18; CRCR 1; CRCR; Deleted in colorectal cancer protein; Deleted in colorectal carcinoma; Netrin receptor DCC; Tumor suppressor protein DCC; DCC_RAT.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  DCC  
• Gene symbol
  DCC
• Short name
  Anti-DCC
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  DCC Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  deleted in colorectal carcinoma, CRC18 and CRCR1 and IGDCC1 and MRMV1 and NTN1R1, DCC and IDBG-3511 and ENSG00000187323 and 1630, identical protein binding, Plasma membranes, Dcc and IDBG-157336 and ENSMUSG00000060534 and 13176

Gene info

• Identity
  HGNC:2701
• Gene
  DCC
• Long gene name
  DCC netrin 1 receptor
• Synonyms gene name
  • deleted in colorectal carcinoma
• Synonyms
  • IGDCC1
  • NTN1R1
• Synonyms name
  • immunoglobulin superfamily, DCC subclass, member 1
• GenBank acession
  • X76132
• Locus
  18q21.2
• Discovery year
  1990-05-25
• Entrez gene record
  1630
• Pubmed identfication
  • 2294591
  • 24400119
• RefSeq identity
  • NM_005215
• Classification
  • Fibronectin type III domain containing
  • MicroRNA protein coding host genes
  • I-set domain containing
• VEGA ID
  OTTHUMG00000132698
• Locus Specific Databases
  • LRG_1107

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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