Cullin 3 Antibody

• Catalog number
  bs-50596R
• Price
  Please ask
• Size
  0.1ml

• Long name
  Cullin 3 Primary Polyclonal Antibody
• Also known as
  Cullin 3 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  Cullin 3
• Specificity
  This is a highly specific antibody against Cullin 3.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  Recombinant human Cullin 3 (a.a 611-768) protein purified from E.coli
• Gene ID number
  8452
• Swiss Prot
  Q13618
• Tested Applications
  WB
• Recommended dilutions
  WB (1:1,000)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Cullins are a family of hydrophobic proteins providing a scaffold for ubiquitin ligases (E3). All eukaryotes appear to have cullins. They combine with RING proteins to form Cullin-RING ubiquitin ligases (CRLs) that are highly diverse and play a role in myriad cellular processes. Human genome contains seven cullin genes. CUL1 (part of SCF complex), CUL2 (part of ECS complex), CUL3 (part of CUL3-BTB complex), CUL4A, CUL4B, CUL5 and CUL7. CUL1, 2, 3, 4A, 4B, 5 and 7 each form part of a multi-subunit ubiquitin complex. Cullin-RING ubiquitin ligases (CRLs), such as Cul1 (SCF) play an essential role in targeting proteins for ubiquitin-mediated destruction; as such, they are diverse in terms of composition and function, regulating many different processes from glucose sensing and DNA replication to limb patterning and circadian rhythms. The catalytic core of CRLs consists of a RING protein and a cullin family member.. Cul3 encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  CUL-3; PHA2E; Cullin-3; CUL3; KIAA0617
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Cullin  
• Gene symbol
  CUL3, DCUN1D3
• Short name
  Anti-Cullin 3
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  Cullin 3 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:2553
• Gene
  CUL3
• Long gene name
  cullin 3
• GenBank acession
  • U58089
• Locus
  2q36.2
• Discovery year
  1998-10-29
• Entrez gene record
  8452
• Pubmed identfication
  • 8681378
  • 17192413
• Classification
  • Cullins
• VEGA ID
  OTTHUMG00000133167

Gene info

• Identity
  HGNC:28734
• Gene
  DCUN1D3
• Long gene name
  defective in cullin neddylation 1 domain containing 3
• Synonyms gene name
  • DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
• Synonyms
  • MGC48972
  • FLJ41725
  • DKFZp686O0290
  • SCCRO3
• GenBank acession
  • BC040442
• Locus
  16p12.3
• Discovery year
  2005-10-04
• Entrez gene record
  123879
• Pubmed identfication
  • 15988528
• RefSeq identity
  • NM_173475
• VEGA ID
  OTTHUMG00000131553

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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