BAP1 (Ser592) Antibody
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Catalog numberbs-3051R
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PricePlease ask
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Size0.1ml
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Long nameBAP1 (Ser592) Primary Polyclonal Antibody
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Also known asBAP1 (Ser592) PAb
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CategoryPrimary Antibodies
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ConjugationUnconjugated
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Target AntigenBAP1 Ser592
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SpecificityThis is a highly specific antibody against BAP1 Ser592. This phosphorylation site is homologous to the Ser590 site in Rat.
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Modification sPhosphorylation
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Modification site sSer592
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ClonalityPolyclonal antibody
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Clone numberPolyclonal antibody
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Concentration1ug per 1ul
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Immunogen range570-620/729
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Subcellular locationCytoplasm, Nucleus
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SourceKLH conjugated synthetic phosphopeptide derived from human BAP1 around the phosphorylation site of Ser592
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Gene ID number8314
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Swiss ProtQ92560
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Tested ApplicationsWB, IHC-P, IF(IHC-P)
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Recommended dilutionsWB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
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Cross reactivityHuman, Rat
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Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the target antigenDeubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Acts as a tumor suppressor.
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Purification methodThis antibody was purified via Protein A.
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Storage conditionsKeep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
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Synonym namesUCHL2; hucep-6; HUCEP-13; Ubiquitin carboxyl-terminal hydrolase BAP1; BRCA1-associated protein 1; Cerebral protein 6; BAP1; KIAA0272
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PropertiesIf you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolBAP1, MAGI1, RNF2
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Short nameAnti-BAP1 Ser592
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TechniqueAntibody, antibodies against human proteins, antibodies for
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HostRabbit (Oryctolagus cuniculus)
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IsotypeImmunoglobulin G (IgG)
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Alternative nameBAP1 (Ser592) Polyclonal Antibody
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene nameBRCA1 associated protein 1
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Synonyms gene name
- BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1998-09-17
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Entrez gene record
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Pubmed identfication
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Classification
- Ubiquitin C-terminal hydrolases
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namemembrane associated guanylate kinase, WW and PDZ domain containing 1
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Synonyms gene
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Synonyms gene name
- BAI1-associated protein 1
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-09-29
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Membrane associated guanylate kinases
- PDZ domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namering finger protein 2
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Synonyms
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GenBank acession
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Locus
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Discovery year1997-06-09
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Ring finger proteins
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data