TLR4 Antibody, Cy7 Conjugated
#
-
Catalog numberbs-1021R-Cy7
-
Price:
-
Size0.1ml
-
-
Long nameTLR4 Polyclonal Antibody, Cy7 Conjugated
-
CategoryConjugated Primary Antibodies
-
ConjugationCy7
-
Host OrganismRabbit (Oryctolagus cuniculus)
-
Target AntigenTLR4
-
SpecificityThis is a highly specific antibody against TLR4.
-
ModificationUnmodified
-
Modification siteNone
-
ClonalityPolyclonal
-
ClonePolyclonal antibody
-
Concentration1ug per 1ul
-
Immunogen_range780-830/835
-
Subcellular locationCytoplasm
-
SourceKLH conjugated synthetic peptide derived from rat TLR4
-
Gene ID number21898
-
Swiss ProtQ9QUK6
-
Tested applicationsFCM, IF(IHC-P), IF(ICC)
-
Recommended dilutionsFCM(1:20-100), IF(IHC-P)(1:50-200), IF(ICC)(1:50-200)
-
CrossreactivityHuman, Mouse, Rat, Bovine
-
Crossreactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
-
Antigen backgroundCooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.
-
Purification methodThis antibody was purified via Protein A.
-
Storage conditionsKeep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
-
Excitation Emission743nm/767nm
-
SynonymsLps; Ly87; Ran/M1; Rasl2-8; Toll-like receptor 4; CD284; Tlr4
-
PropertiesIf you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
ConjugatedThese antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths.
-
Additional conjugationCy7
-
French translationanticorps
-
Gene target
-
Gene symbolTLR4
-
Short nameAnti-TLR4
-
TechniqueAntibody, antibodies against human proteins, antibodies for, antibody Conjugates
-
IsotypeImmunoglobulin G (IgG)
-
LabelCy7
-
Alternative nameAnti-TLR4 PAb Cy7
-
Alternative techniqueantibodies
-
Alternative to gene targettoll-like receptor 4, ARMD10 and CD284 and TLR-4 and TOLL, TLR4 and IDBG-82738 and ENSG00000136869 and 7099, protein binding, Cell surfaces, Tlr4 and IDBG-156729 and ENSMUSG00000039005 and 21898, TLR4 and IDBG-638758 and ENSBTAG00000006240 and 281536
-
Gene info
-
Identity
-
Gene
-
Long gene nametoll like receptor 4
-
Synonyms gene name
- toll-like receptor 4
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1998-06-25
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Toll like receptors
- CD molecules
-
VEGA ID
-
Locus Specific Databases
MeSH Data
-
Name
-
ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data