- Catalog numberbs-1021R-PE
- Product nameTLR4 Antibody, PE Conjugated
- Size0.1ml
- PriceAsk For Price
- Short nameAnti-TLR4
- Long nameTLR4 Polyclonal Antibody, PE Conjugated
- CategoryConjugated Primary Antibodies
- ConjugationPE
- Host OrganismRabbit (Oryctolagus cuniculus)
- Target AntigenTLR4
- SpecificityThis is a highly specific antibody against TLR4.
- ModificationUnmodified
- Modification siteNone
- ClonalityPolyclonal
- ClonePolyclonal antibody
- IsotypeImmunoglobulin G (IgG)
- Concentration1ug per 1ul
- Immunogen range780-830/835
- Subcellular locationCytoplasm
- SourceKLH conjugated synthetic peptide derived from rat TLR4
- Gene ID number21898
- Swiss ProtQ9QUK6
- Tested applicationsFCM
- Recommended dilutionsFCM(1:20-100)
- CrossreactivityHuman, Mouse, Rat, Bovine
- Crossreactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
- Antigen backgroundCooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.
- Purification methodThis antibody was purified via Protein A.
- Storage conditionsKeep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
- Excitation Emission480,565nm/578nm
- SynonymsLps; Ly87; Ran/M1; Rasl2-8; Toll-like receptor 4; CD284; Tlr4
- Alternative to gene target
- [ "toll-like receptor 4", "ARMD10 and CD284 and TLR-4 and TOLL", "TLR4 and IDBG-82738 and ENSG00000136869 and 7099", "protein binding", "Cell surfaces", "Tlr4 and IDBG-156729 and ENSMUSG00000039005 and 21898", "TLR4 and IDBG-638758 and ENSBTAG00000006240 and 281536" ]
- Gene targetTLR4 PE Conjugated
- Identity:HGNC:11850
- Gene:TLR4
- Long gene name:toll like receptor 4
- Synonyms gene name:toll-like receptor 4
- Synonyms:hTollCD284TLR-4ARMD10
- Discovery year:1998-06-25
- Entrez gene record:7099
- Pubmed identification:9435236, 9237759
- RefSeq identity:NM_138554
- Classification:Toll like receptors, CD molecules
- VEGA ID:OTTHUMG00000021046
- Gene symbolTLR4
- isotype filter
- Immunoglobulin G IgG
- LabelPE
- label filter
- PE
- technique filter
- Antibody
- TechniqueAntibody, antibodies against human proteins, antibodies for, antibody Conjugates
- Alternative techniqueantibodies
Gene info
Locus Specific Databases:LRG_320