LRP6 (Ser1490) Antibody, Cy3 Conjugated
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Catalog number
bs-3253R-Cy3
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Price
Please ask
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Size
0.1ml
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Long name
LRP6 (Ser1490) Polyclonal Antibody, Cy3 Conjugated
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Category
Conjugated Primary Antibodies
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Conjugation
Cy3
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Host Organism
Rabbit (Oryctolagus cuniculus)
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Target Antigen
LRP6 Ser1490
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Specificity
This is a highly specific antibody against LRP6 Ser1490.
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Modification
Phosphorylation
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Modification site
Ser1490
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Clonality
Polyclonal
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Clone
Polyclonal antibody
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Concentration
1ug per 1ul
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Immunogen_range
1470-1520/1613
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Subcellular location
Cytoplasm
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Source
KLH conjugated synthetic phosphopeptide derived from human LRP6 around the phosphorylation site of Ser1490
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Gene ID number
4040
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Swiss Prot
O75581
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Tested applications
IF(IHC-P), IF(ICC)
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Recommended dilutions
IF(IHC-P)(1:50-200), IF(ICC)(1:50-200)
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Crossreactivity
Human, Mouse
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Crossreactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Antigen background
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).
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Purification method
This antibody was purified via Protein A.
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Storage conditions
Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
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Excitation Emission
512,550nm/570,615nm
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Synonyms
ADCAD2; Low-density lipoprotein receptor-related protein 6; LRP-6; LRP6
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Properties
If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser. 1 of the Anti-LRP6 Ser1490 can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC. This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy.
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Additional conjugation
cy3 conjugation kit
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French translation
anticorps
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Gene target
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Gene symbol
LRP6
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Short name
Anti-LRP6 Ser1490
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Technique
Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
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Isotype
Immunoglobulin G (IgG)
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Label
Cy3
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Alternative name
Anti-LRP6 Ser1490 PAb Cy3
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Alternative technique
antibodies
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Alternative to gene target
low density lipoprotein receptor-related protein 6, ADCAD2, LRP6 and IDBG-20075 and ENSG00000070018 and 4040, coreceptor activity involved in Wnt receptor signaling pathway, Cell surfaces, Lrp6 and IDBG-194033 and ENSMUSG00000030201 and 102642234,16974, LRP6 and IDBG-639434 and ENSBTAG00000011761 and 536328
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Gene info
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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