LRP6 (Ser1490) Antibody, ALEXA FLUOR 488
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Catalog number
bs-3253R-A488
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Price
Please ask
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Size
100ul
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Long name
LRP6 (Ser1490) Polyclonal Antibody, ALEXA FLUOR 488 Conjugated
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Also known as
Anti-LRP6 Ser1490 PAb ALEXA FLUOR 488
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Category
Conjugated Primary Antibodies
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Conjugated with
ALEXA FLUOR® 488
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Host Organism
Rabbit (Oryctolagus cuniculus)
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Target Antigen
LRP6 Ser1490
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Specificity
This is a highly specific antibody against LRP6 Ser1490.
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Modification
Phosphorylation
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Modification Site
Ser1490
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Clonality
Polyclonal
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Clone
Polyclonal antibody
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Concentration
1ug per 1ul
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Immunogen range
1470-1520/1613
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Subcellular location
Cytoplasm
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Source
KLH conjugated synthetic phosphopeptide derived from human LRP6 around the phosphorylation site of Ser1490
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Gene ID Number
4040
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Swiss Prot
O75581
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Tested applications
IF(IHC-P), IF(ICC)
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Recommended dilutions
IF(IHC-P)(1:50-200), IF(ICC)(1:50-200)
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Crossreactivity
Human, Mouse
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Cross reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the antigen
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).
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Purification
Purified by Protein A.
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Storage conditions
Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
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Excitation emission
499nm/519nm
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Synonyms
ADCAD2; Low-density lipoprotein receptor-related protein 6; LRP-6; LRP6
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Properties
For facs or microscopy Alexa 1 conjugate. Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), yet the Anti-LRP6 Ser1490 has a very high photo stability. As a result of this photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry. It is distinguished in the FL1 of a FACS-Calibur or FACScan. Also Alexa Fluor 488 is pH stable. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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Conjugation
Alexa Fluor
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French translation
anticorps
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Gene target
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Gene symbol
LRP6
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Short name
Anti-LRP6 Ser1490
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Technique
Antibody, antibodies against human proteins, antibodies for
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Isotype
Immunoglobulin G (IgG)
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Label
ALEXA FLUOR 488
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Alternative name
LRP6 (Ser1490) Polyclonal Antibody, ALEXA FLUOR 488
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Alternative technique
antibodies
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Alternative to gene target
low density lipoprotein receptor-related protein 6, ADCAD2, LRP6 and IDBG-20075 and ENSG00000070018 and 4040, coreceptor activity involved in Wnt receptor signaling pathway, Cell surfaces, Lrp6 and IDBG-194033 and ENSMUSG00000030201 and 102642234,16974, LRP6 and IDBG-639434 and ENSBTAG00000011761 and 536328
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Gene info
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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