DC-SIGN Antibody, FITC Conjugated

• Catalog number
  bs-10053R-FITC
• Price
  Please ask
• Size
  0.1ml

• Long name
  DC-SIGN Polyclonal Antibody, FITC Conjugated
• Category
  Conjugated Primary Antibodies
• Conjugation
  FITC
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  DC-SIGN
• Specificity
  This is a highly specific antibody against DC-SIGN.
• Modification
  Unmodified
• Modification site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Subcellular location
  Extracellular
• Source
  KLH conjugated synthetic peptide derived from human DC-SIGN/CD209
• Gene ID number
  30835
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human
• Crossreactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Antigen background
  Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV1, HIV2 and SIV bind to DCs via DCSIGN. ICAM3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed CD299, DC-SIGNR, L-SIGN and DCSIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
• Excitation Emission
  494nm/518nm
• Synonyms
  CLEC4L; Dendritic cell-specic ICAM-3-grabbing non-integrin 1; C type lectin domain family 4 member L; CD 209; CD209; CD209 antigen; CD209 antigen-like protein A; CD209 molecule; Cd209a; CDSIGN; CIRE; DC SIGN1; DCSIGN; Dendritic cell specic ICAM 3 grabbing nonintegrin 1; Dendritic cell specic ICAM3 grabbing nonintegrin 1; Dendritic cell-specic intracellular adhesion molecules ICAM-3 grabbing non-integrin; Dengue fever, protection against, included; Dentritic Cell Specic ICAM3 Grabbing Nonintegrin; HIV GP120 Binding Protein; MGC129965; MGC130443; SIGN-R1; SIGNR5; CD209_HUMAN.
• Properties
  If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS. When excited at 488 nanometers, FITC has a green emission that's usually collected at 530 nanometers, the FL1 detector of a FACSCalibur or FACScan. FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light. For fluorescent microscopy applications, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept. Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes.
• Additional conjugation
  Anti-FITC Antibody
• French translation
  anticorps

• Gene target
  DC-SIGN   Conjugated  
• Gene symbol
  CD209, CLEC4M, UBTD2, WFDC21P, TSPAN14, DCSTAMP, DCX, LAMP3, PDCD1LG2, CCL18
• Short name
  Anti-DC-SIGN
• Technique
  Antibody, FITC, antibodies against human proteins, antibodies for, antibody Conjugates, Fluorescein
• Isotype
  Immunoglobulin G (IgG)
• Label
  FITC
• Alternative name
  Anti-DC-SIGN PAb FITC
• Alternative technique
  antibodies, fluorescine

Gene info

• Identity
  HGNC:1641
• Gene
  CD209
• Long gene name
  CD209 molecule
• Synonyms gene name
  • CD209 antigen
• Synonyms
  • DC-SIGN
  • hDC-SIGN
  • CDSIGN
  • DC-SIGN1
  • CLEC4L
• GenBank acession
  • M98457
• Locus
  19p13.2
• Discovery year
  2000-07-19
• Entrez gene record
  30835
• Pubmed identfication
  • 1518869
• RefSeq identity
  • NM_021155
• Classification
  • Scavenger receptors
  • C-type lectin domain containing
  • CD molecules
• VEGA ID
  OTTHUMG00000182530

Gene info

• Identity
  HGNC:13523
• Gene
  CLEC4M
• Long gene name
  C-type lectin domain family 4 member M
• Synonyms gene
  • CD209L
  • CD299
• Synonyms gene name
  • CD299 antigen
  • C-type lectin domain family 4, member M
• Synonyms
  • HP10347
  • DC-SIGNR
  • LSIGN
  • DCSIGNR
  • DC-SIGN2
• GenBank acession
  • AB015629
• Locus
  19p13.2
• Discovery year
  2000-09-19
• Entrez gene record
  10332
• Pubmed identfication
  • 10072769
• RefSeq identity
  • NM_014257
• Classification
  • CD molecules
• VEGA ID
  OTTHUMG00000182432

Gene info

• Identity
  HGNC:24463
• Gene
  UBTD2
• Long gene name
  ubiquitin domain containing 2
• Synonyms
  • DC-UbP
  • MGC30022
• Synonyms name
  • dendritic cell derived ubiquitin like protein
• GenBank acession
  • AF251700
• Locus
  5q35.1
• Discovery year
  2006-11-06
• Entrez gene record
  92181
• Pubmed identfication
  • 12507522
• RefSeq identity
  • NM_152277
• VEGA ID
  OTTHUMG00000130519

Gene info

• Identity
  HGNC:50357
• Gene
  WFDC21P
• Long gene name
  WAP four-disulfide core domain 21, pseudogene
• Synonyms
  • LOC645638
  • lnc-DC
  • LNCDC
• Synonyms name
  • long non-coding RNA, dendritic cell differentiation
  • WDNM1-like, pseudogene
  • lnc-dendritic cell lncRNA
• Locus
  17q23.1
• Discovery year
  2014-06-16
• Entrez gene record
  645638
• Pubmed identfication
  • 24744378
  • 26158411
• RefSeq identity
  • NR_030732
• VEGA ID
  OTTHUMG00000176074

Gene info

• Identity
  HGNC:23303
• Gene
  TSPAN14
• Long gene name
  tetraspanin 14
• Synonyms gene
  • TM4SF14
• Synonyms gene name
  • transmembrane 4 superfamily member 14
• Synonyms
  • DC-TM4F2
  • MGC11352
• GenBank acession
  • AF311903
• Locus
  10q23.1
• Discovery year
  2004-10-19
• Entrez gene record
  81619
• Pubmed identfication
  • 11230166
• RefSeq identity
  • NM_030927
• Classification
  • Tetraspanins
• VEGA ID
  OTTHUMG00000018615

Gene info

• Identity
  HGNC:18549
• Gene
  DCSTAMP
• Long gene name
  dendrocyte expressed seven transmembrane protein
• Synonyms gene
  • TM7SF4
• Synonyms gene name
  • transmembrane 7 superfamily member 4
• Synonyms
  • DC-STAMP
  • FIND
• Synonyms name
  • Dendritic cells (DC)-specific transmembrane protein
  • IL-Four INDuced
• GenBank acession
  • AF305068
• Locus
  8q22.3
• Discovery year
  2004-06-25
• Entrez gene record
  81501
• Pubmed identfication
  • 11169400
  • 11345591
• RefSeq identity
  • NM_030788
• VEGA ID
  OTTHUMG00000164890

Gene info

• Identity
  HGNC:2714
• Gene
  DCX
• Long gene name
  doublecortin
• Synonyms gene name
  • doublecortex; lissencephaly, X-linked (doublecortin)
• Synonyms
  • SCLH
  • DC
  • LISX
  • DBCN
  • XLIS
• Synonyms name
  • doublecortex
• GenBank acession
  • AF040254
• Locus
  Xq23
• Discovery year
  1998-03-24
• Entrez gene record
  1641
• Pubmed identfication
  • 9489699
  • 9489700
• RefSeq identity
  • NM_178153
• Classification
  • Doublecortin superfamily
• VEGA ID
  OTTHUMG00000022204

Gene info

• Identity
  HGNC:14582
• Gene
  LAMP3
• Long gene name
  lysosomal associated membrane protein 3
• Synonyms gene name
  • lysosomal-associated membrane protein 3
• Synonyms
  • LAMP
  • TSC403
  • DC-LAMP
  • DCLAMP
  • CD208
• GenBank acession
  • AB013924
• Locus
  3q27.1
• Discovery year
  2001-06-29
• Entrez gene record
  27074
• Pubmed identfication
  • 9721848
• Classification
  • Lysosome associated membrane proteins
  • CD molecules
• VEGA ID
  OTTHUMG00000158387

Gene info

• Identity
  HGNC:18731
• Gene
  PDCD1LG2
• Long gene name
  programmed cell death 1 ligand 2
• Synonyms
  • PD-L2
  • Btdc
  • PDL2
  • bA574F11.2
  • CD273
  • B7-DC
• Synonyms name
  • B7 dendritic cell molecule
• GenBank acession
  • AF344424
• Locus
  9p24.1
• Discovery year
  2003-11-14
• Entrez gene record
  80380
• Pubmed identfication
  • 11224527
• RefSeq identity
  • NM_025239
• Classification
  • B7 family
  • CD molecules
  • Immunoglobulin like domain containing
  • Receptor ligands
• VEGA ID
  OTTHUMG00000019504

Gene info

• Identity
  HGNC:10616
• Gene
  CCL18
• Long gene name
  C-C motif chemokine ligand 18
• Synonyms gene
  • SCYA18
• Synonyms gene name
  • small inducible cytokine subfamily A (Cys-Cys), member 18, pulmonary and activation-regulated
  • chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
  • chemokine (C-C motif) ligand 18
• Synonyms
  • DC-CK1
  • PARC
  • AMAC-1
  • DCCK1
  • MIP-4
  • CKb7
• Synonyms name
  • pulmonary and activation-regulated
• GenBank acession
  • Y13710
• Locus
  17q12
• Discovery year
  1997-01-08
• Entrez gene record
  6362
• Pubmed identfication
  • 9233607
  • 10049593
• RefSeq identity
  • NM_002988
• Classification
  • Chemokine ligands
• VEGA ID
  OTTHUMG00000188410

MeSH Data

• Name
  Fluorescent Antibody Technique
• Concept
  Scope note: Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
• Tree numbers
  • E01.370.225.500.607.512.240
  • E01.370.225.750.551.512.240
  • E05.200.500.607.512.240
  • E05.200.750.551.512.240
  • E05.478.583.375
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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