MAP 1A/1B LC3 A/B Antibody, ALEXA FLUOR 555
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Catalog numberbs-4309R-A555
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PricePlease ask
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Size100ul
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Long nameMAP 1A/1B LC3 A/B Polyclonal Antibody, ALEXA FLUOR 555 Conjugated
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Also known asAnti-MAP 1A/1B LC3 Alpha/Beta PAb ALEXA FLUOR 555
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CategoryConjugated Primary Antibodies
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Conjugated withALEXA FLUOR® 555
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Host OrganismRabbit (Oryctolagus cuniculus)
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Target AntigenMAP 1A/1B LC3 Alpha/Beta
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SpecificityThis is a highly specific antibody against MAP 1A/1B LC3 Alpha/Beta.
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ModificationUnmodified
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Modification SiteNone
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ClonalityPolyclonal
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ClonePolyclonal antibody
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Concentration1ug per 1ul
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Immunogen range20-70/121
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Subcellular locationCytoplasm, Cell membrane
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SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MAP LC3 Alpha
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Gene ID Number54901, 84557
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Swiss ProtQ9H492, Q9GZQ8
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Tested applicationsIF(IHC-P)
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Recommended dilutionsIF(IHC-P)(1:50-200)
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CrossreactivityHuman, Mouse, Rat
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Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the antigenMicrotubule-associated proteins (MAPs) regulate microtubule stability and play critical roles in neuronal development and in maintaining the balance between neuronal plasticity and rigidity. MAP-light chain 3 beta (MAP-LC3 Beta) and MAP-light chain 3 alpha (MAP-LC3 alpha) are subunits of both MAP1A and MAP1B. MAP-LC3M Beta, a homolog of Apg8p, is essential for autophagy and associated to the autophagosome membranes after processing. Two forms of LC3 Beta, the cytosolic LC3-I and the membrane-bound LC3-II, are produced post-translationally. LC3-I is formed by the removal of the C-terminal 22 amino acids from newly synthesized LC3∫, followed by the conversion of a fraction of LC3-I into LC3-II. LC3 enhances fibronectin mRNA translation in ductus arteriosus cells through association with 60S ribosomes and binding to an AU-rich element in the 3’ untranslated region of fibronectin mRNA. This facilitates sorting of fibronectin mRNA onto rough endoplasmic reticulum and translation. MAP LC3 Beta may also be involved in formation of autophagosomal vacuoles. It is expressed primarily in heart, testis, brain and skeletal muscle.
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PurificationPurified by Protein A.
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Storage conditionsStore this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
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Excitation emission553nm/568nm
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SynonymsMicrotubule-associated proteins 1A/B light chain 3A; Microtubule-associated proteins 1A/B light chain 3B; Microtubule-associated proteins 1Beta light chain 3A; Microtubule-associated proteins 1Beta light chain 3A; MAP1B LC3 A; MAP LC3 Beta; MAP-LC3 Beta; MAP1 light chain 3-like protein 1.MAP1LC3B.MLP3A_HUMAN
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PropertiesFor facs or microscopy Alexa 1 conjugate. Very high photo stable ALEXA conjugate. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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ConjugationAlexa Fluor, ALEXA FLUOR 555
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French translationanticorps
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Gene target
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Gene symbolMOAP1, MAP7, MASP2, MAP1LC3A, MASP1
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Short nameAnti-MAP 1A/1B LC3 Alpha/Beta
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TechniqueAntibody, antibodies against human proteins, antibodies for
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IsotypeImmunoglobulin G (IgG)
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LabelALEXA FLUOR 555
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Alternative nameMAP 1A/1B LC3 A/B Polyclonal Antibody, ALEXA FLUOR 555
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namemodulator of apoptosis 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2002-11-13
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Entrez gene record
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Pubmed identfication
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Classification
- Paraneoplastic Ma antigens
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemicrotubule associated protein 7
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1999-01-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameMBL associated serine protease 2
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Synonyms gene
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Synonyms gene name
- mannan-binding lectin serine protease 2
- mannan-binding lectin serine peptidase 1 pseudogene 1
- mannan-binding lectin serine protease 1 pseudogene 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1998-12-17
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Sushi domain containing
- Complement system activation components
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namemicrotubule associated protein 1 light chain 3 alpha
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Synonyms
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Locus
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Discovery year2000-06-29
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Autophagy related
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameMBL associated serine protease 1
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Synonyms gene
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Synonyms gene name
- mannan-binding lectin serine protease 1 (C4/C2 activating component of Ra-reactive factor)
- mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
- mannan binding lectin serine peptidase 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1995-07-06
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Serine proteases
- Complement system activation components
- Sushi domain containing
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data