Anti-gamma Crystallin (Polyclonal), ALEXA Fluor 594

• Catalog number
  GENTObs-13276R-A594
• Price
  Please ask
• Size
  100 microliters

• Type
  Conjugated Primary Antibody
• Conjugated with
  ALEXA FLUOR® 594
• Host organism
  Rabbit (Oryctolagus cuniculus)
• Target Protein Peptide
  gamma Crystallin
• Specificity
  This antibody reacts specifically with gamma Crystallin
• Modification
  No modification has been applied to this antibody
• Modification site
  None
• Clonality
  Polyclonal Antibody
• Clone
  Polyclonal Antibodies
• Concentration
  1ug per 1ul
• Subcellular locations
  Cytoplasm, Nucleus
• Antigen Source
  KLH conjugated synthetic peptide derived from human gamma C Crystallin/CRYG3
• Gene ID
  1420, 1419, 1418, 1421, 1422
• Swiss Prot
  N/A
• Applications
  IF(IHC-P)
• Applications with corresponding dilutions
  IF(IHC-P)(1:50-200)
• Cross reactive species
  Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)
• Cross Reactive Species details
  No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
• Background information
  Crystallins are the major proteins of the vertebrate eye lens, where they maintain the transparency and refractive index of the lens. Crystallins are divided into alpha, beta, and gamma families, and the beta and gamma-crystallins also comprise a superfamily. Crystallins usually contain seven distinctive protein regions, including four homologous motifs, a connecting peptide, and N- and C-terminal extensions. gamma-crystallins are structural proteins in the lens, and they exists as monomers which typically lack connecting peptides and terminal extensions. The gamma-crystallins include seven closely related gamma A, gamma B, gamma C, gamma D, gamma E, gamma F, and gamma G-crystallin, as well as the gamma N and gamma S-crystallin genes. The gamma-crystallins are differentially regulated after early development, and are involved in cataract formation as a result of either age-related protein degradation or genetic mutation.
• Purification method
  Purified by Protein A.
• Storage
  Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
• Excitation emission
  590nm/617nm
• Synonyms
  CRYG3; CRYG1; CRYG2; CRYG4; CRYG5;Gamma-crystallin 5; Gamma-crystallin 4; Gamma-crystallin 1; Gamma-crystallin 2; Gamma-crystallin 3.
• Also known as
  gamma Crystallin Polyclonal Antibody
• Other name
  Anti-gamma Crystallin Polyclonal
• Advisory
  Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
• Properties
  For facs or microscopy Alexa 1 conjugate.
• Conjugation
  Alexa Fluor, ALEXA FLUOR® 594
• Conjugated
  Alexa conjugate 1
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Group
  Polyclonals and antibodies
• About
  Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.

• Gene target
  gamma   Crystallin  
• Gene symbol
  CRYGS, CRYGB, CRYGN
• Short name
  Anti-gamma Crystallin
• Technique
  Polyclonal, anti-, anti, antibody to, antibodies, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 594
• Alternative name
  gamma Crystallin Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated
• Alternative technique
  polyclonals, antibodies

Gene info

• Identity
  HGNC:2417
• Gene
  CRYGS
• Long gene name
  crystallin gamma S
• Synonyms gene
  • CRYG8
• Synonyms gene name
  • crystallin, gamma S
• Synonyms name
  • crystallin, gamma 8
• Locus
  3q27.3
• Discovery year
  1989-05-25
• Entrez gene record
  1427
• RefSeq identity
  • NM_017541
• Classification
  • Beta-gamma crystallins
• VEGA ID
  OTTHUMG00000156615
• Locus Specific Databases
  • Global Variome shared LOVD

Gene info

• Identity
  HGNC:2409
• Gene
  CRYGB
• Long gene name
  crystallin gamma B
• Synonyms gene
  • CRYG2
• Synonyms gene name
  • crystallin, gamma 1-2
  • crystallin, gamma B
• Locus
  2q33.3
• Discovery year
  1986-01-01
• Entrez gene record
  1419
• RefSeq identity
  • NM_005210
• Classification
  • Beta-gamma crystallins
• VEGA ID
  OTTHUMG00000132941

Gene info

• Identity
  HGNC:20458
• Gene
  CRYGN
• Long gene name
  crystallin gamma N
• Synonyms gene name
  • crystallin, gamma N
• GenBank acession
  • AF445455
• Locus
  7q36.1
• Discovery year
  2003-02-25
• Entrez gene record
  155051
• Classification
  • MicroRNA protein coding host genes
  • Beta-gamma crystallins
• VEGA ID
  OTTHUMG00000157353

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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