BECN1 Polyclonal Antibody
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Catalog number
CAC07912
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Price
Please ask
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Size
100 μg
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Other name
Beclin-1,Coiled-coil myosin-like BCL2-interacting protein,Protein GT197,Beclin-1-C 35 kDa,BECN1,GT197
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Immunogen
Recombinant Human Beclin-1 protein (1-100AA)
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Verified reactivity
Human, Mouse
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Verified applications
ELISA,WB,IHC,IF. Recommended dilution:WB:1:500-1:5000,IHC:1:20-1:200,IF:1:50-1:200
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Raised in
Rabbit
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Clonality
Polyclonal
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Protein number
Q14457
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Gene number
Please refer to GenBank
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NCBI number
Please refer to NCBI
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Purity
Protein G purified, >95%
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Storage recommendation
Aliquot and store at -20°C. Minimize freezing and thawing.
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Use before
1 year
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Shipping requirements
Blue ice
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Estimated production time
3-7 business days
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Supplementary information
Plays a central role in autophagy (PubMed:23184933). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense.
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Notes
For research use only. Not for diagnostic procedures.
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Properties
If you buy Antibodies supplied by bioma they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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Group
Polyclonals and antibodies
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About
Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
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French translation
anticorps
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Gene target
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Gene symbol
BECN1
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Short name
BECN1 Polyclonal Antibody
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Technique
Polyclonal, Antibody, antibodies against human proteins, antibodies for, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
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Label
Unconjugated
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Alternative name
beclin 1, autophagy related polyclonal (antibody to-)
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Alternative technique
polyclonals, antibodies
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Alternative to gene target
beclin 1, autophagy related, ATG6 and beclin1 and VPS30, BECN1 and IDBG-51769 and ENSG00000126581 and 102725513,8678, sequence-specific DNA binding, Plasma membranes, Becn1 and IDBG-212053 and ENSMUSG00000035086 and 56208, BECN1 and IDBG-640456 and ENSBTAG00000019914 and 527278
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Gene info
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Identity
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Gene
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Long gene name
beclin 1
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Synonyms gene name
- beclin 1 (coiled-coil, moesin-like BCL2 interacting protein)
- beclin 1, autophagy related
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
1998-11-27
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- PIK3C3 complex subunits
- MicroRNA protein coding host genes
- Autophagy related
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VEGA ID
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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