TAE-226

• Catalog number
  9436-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  2-((5-chloro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide; NVP-TAE226
• Description
  TAE-226 is a potent ATP-competitive inhibitor of FAK and IGF-IR with potential anticancer activity. TAE-226 can block FAK and IGF-IR signaling pathways. TAE-226 inhibits the phosphorylation of FAK as well as the downstream effectors AKT, extracellular signal-related kinase, and S6 ribosomal protein in multiple glioma cell lines.
• CAS Number
  761437-28-9
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₃H₂₅ClN₆O₃
• Molecular Weight
  468.94
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>5 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent, ATP-competitive inhibitor of FAK and IGF-IR
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  9934347
• PubChem CID Link
• SMILES
  CNC(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCOCC4)OC
• InChi
  InChI=1S/C23H25ClN6O3/c1-25-22(31)16-5-3-4-6-18(16)27-21-17(24)14-26-23(29-21)28-19-8-7-15(13-20(19)32-2)30-9-11-33-12-10-30/h3-8,13-14H,9-12H2,1-2H3,(H,25,31)(H2,26,27,28,29)
• InChi Key
  UYJNQQDJUOUFQJ-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  TAE-226  
• Short name
  TAE-226
• Alternative name
  Tris acetic EDTA-226

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