Sulfo-LC-SPDP

• Catalog number
  2325-50
• Price
  Please ask
• Size
  50 mg

• Alternative_name
  Sulfosuccinimidyl 6-(3'-[2-pyridyldithio]-propionamido)hexanoate
• Description
  KEY FEATURES: • Sulfo-LC-SPDP releases a byproduct, pyridine-2-thione after reacting with free sulfhydryl groups. By measuring the release of this byproduct at 343 nm, the reaction can be easily followed • Amine-reactive; the "long chain" Sulfo-LC-SPDP crosslinking reagent has a 15.7 Å spacer arm • More water-soluble than the corresponding LC-SPDP • Membrane-impermeable which enables crosslinking on cell surface • The cleavable spacer arm enables separation of cross-linked products APPLICATIONS: • Reversible crosslinking of proteins • N-hydroxysulfosuccinimide (Sulfo-NHS) ester that reacts with primary amines, as found in lysine side chains • Sulfo-LC-SPDP crosslinking molecule pyridinyldisulfide reacts with sulhydryls to yield a reversible disulfide bond.
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₈H₂₂O₈N₃S₃Na
• Molecular Weight
  527.57
• Cell Permeable
  No
• Purity
  ≥90% by NMR
• Solubilities
  H₂O (~ 6 mg/ml)
• Handling
  Protect from moisture
• Tag Line
  A water-soluble, amine and thiol (sulfhydryl) reactive heterobifunctional crosslinking reagent.
• Storage Condition
  -20 ̊C
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• SMILES
  O=C(CC1S(=O)(O[Na])=O)N(OC(CCCCCNC(CCSSC2=CN=CC=C2)=O)=O)C1=O
• InChi
  InChI=1S/C18H23N3O8S3.Na/c22-15(7-10-30-31-13-5-4-8-19-12-13)20-9-3-1-2-6-17(24)29-21-16(23)11-14(18(21)25)32(26,27)28;/h4-5,8,12,14H,1-3,6-7,9-11H2,(H,20,22)(H,26,27,28);/q;+1/p-1
• InChi Key
  JYGUAOMOEQATKJ-UHFFFAOYSA-M
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Sulfo-LC-SPDP  
• Gene symbol
  PTPN7, CT83
• Short name
  Sulfo-LC-SPDP
• Alternative name
  Sulfo-LC-SPDP

Gene info

• Identity
  HGNC:9659
• Gene
  PTPN7
• Long gene name
  protein tyrosine phosphatase non-receptor type 7
• Synonyms
  • HEPTP
  • LC-PTP
• GenBank acession
  • BC001746
• Locus
  1q32.1
• Discovery year
  1993-03-03
• Entrez gene record
  5778
• Pubmed identfication
  • 1510684
• RefSeq identity
  • NM_002832
• Classification
  • Protein tyrosine phosphatases non-receptor type
• VEGA ID
  OTTHUMG00000035931

Gene info

• Identity
  HGNC:33494
• Gene
  CT83
• Long gene name
  cancer/testis antigen 83
• Synonyms gene
  • CXorf61
• Synonyms gene name
  • chromosome X open reading frame 61
• Synonyms
  • KK-LC-1
  • FLJ20611
  • FLJ22913
• Synonyms name
  • Kita-kyushu lung cancer antigen 1
• GenBank acession
  • BC062223
• Locus
  Xq23
• Discovery year
  2007-06-20
• Entrez gene record
  203413
• Pubmed identfication
  • 16651449
• RefSeq identity
  • NM_001017978
• VEGA ID
  OTTHUMG00000022244

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