OVA Conjugated p53 Upregulated Modulator Of Apoptosis (PUMA)
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Catalog number
MBS2086492
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Price
Please ask
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Size
0,01 mg
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Other size
please contact us to order other different size
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Description
This 1 is suited for programmed cell-death studies.
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Gene
Ovalbumin (abbreviated OVA) is the main protein found in egg white, making up 60-65% of the total protein. Ovalbumin displays sequence and three-dimensional homology to the serpin superfamily, but unlike most serpins it is not a serine protease inhibitor. The function of ovalbumin is unknown, although it is presumed to be a storage protein. OVA is also the best characterized and the first antigen proteins used as a transgene to make transgenic mice. Many different transgenic mouse models have systemic OVA expression driven by the ubiquitously expressed b-actin promoter or tissue-specific OVA expression with insulin promoter to drive the transgene expression, for studying type I diabetes, or in different isoforms, secreted or cell-membrane associated, and more recently as inducible transgene models. These C57BL/6 mice, BALB/c mice models are well characterized, and have contributed to our understanding of immunogenicity and tolerance by the OVA model.
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Gene target
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Gene symbol
BBC3, HCAR2
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Short name
OVA Conjugated p53 Upregulated Modulator Of Apoptosis (PUMA)
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Technique
apoptosis, apoptosis pathway, antibody Conjugates
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Alternative name
OVA coupled p53 Upregulated Modulator on programmed cellular destruction (PUMA)
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Alternative technique
celldeath
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Gene info
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Identity
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Gene
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Long gene name
BCL2 binding component 3
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
2002-07-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- BCL2 homology region 3 (BH3) only
- MicroRNA protein coding host genes
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VEGA ID
Gene info
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