TAME Hydrochloride

• Catalog number
  2050-1000
• Price
  Please ask
• Size
  1 g

• Alternative_name
  N-p-Tosyl-L-arginine methyl ester hydrochloride
• Description
  A small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor that stabilizes APC/C substrates in mitotic Xenopus extracts. TAME binds to APC and prevents its activation by Cdc20 and Cdh1. In the absence of APC substrates, TAME ejects Cdc20 from the APC by promoting Cdc20 autoubiquitination in its N-terminal region. TAME also stabilizes cyclin B1 by prematurely terminating ubiquitination.
• CAS Number
  1784-03-8
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₄H₂₂N₄O₄S.HCl
• Molecular Weight
  378.87
• Cell Permeable
  No
• Purity
  ≥98% by TLC
• Solubilities
  Water (50 mg/ml)
• Handling
  Protect from air and moisture
• Tag Line
  An anaphase-promoting complex/cyclosome (APC/C) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD00012578
• PubChem CID
  3083734
• PubChem CID Link
• SMILES
  CC1=CC=C(C=C1)S(=O)(=O)NC(CCCN=C(N)N)C(=O)OC.Cl
• InChi
  InChI=1S/C14H22N4O4S.ClH/c1-10-5-7-11(8-6-10)23(20, 21)18-12(13(19)22-2)4-3-9-17-14(15)16;/h5-8,12,18H,3-4,9H2,1-2H3,(H4,15,16,17);1H
• InChi Key
  JIQFFACVQXXHMY-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  TAME   Hydrochloride  
• Short name
  TAME Hydrochloride
• Alternative name
  TAME Hydrochloride

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