TAME Hydrochloride
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Catalog number2050-500
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Price:
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Size500 mg
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Alternative_nameN-p-Tosyl-L-arginine methyl ester hydrochloride
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DescriptionA small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor that stabilizes APC/C substrates in mitotic Xenopus extracts. TAME binds to APC and prevents its activation by Cdc20 and Cdh1. In the absence of APC substrates, TAME ejects Cdc20 from the APC by promoting Cdc20 autoubiquitination in its N-terminal region. TAME also stabilizes cyclin B1 by prematurely terminating ubiquitination.
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CAS Number1784-03-8
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₁₄H₂₂N₄O₄S.HCl
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Molecular Weight378.87
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Cell PermeableNo
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Purity≥98% by TLC
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SolubilitiesWater (50 mg/ml)
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HandlingProtect from air and moisture
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Tag LineAn anaphase-promoting complex/cyclosome (APC/C) inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life24 months
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MDL NumberMFCD00012578
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PubChem CID3083734
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SMILESCC1=CC=C(C=C1)S(=O)(=O)NC(CCCN=C(N)N)C(=O)OC.Cl
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InChiInChI=1S/C14H22N4O4S.ClH/c1-10-5-7-11(8-6-10)23(20, 21)18-12(13(19)22-2)4-3-9-17-14(15)16;/h5-8,12,18H,3-4,9H2,1-2H3,(H4,15,16,17);1H
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InChi KeyJIQFFACVQXXHMY-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Short nameTAME Hydrochloride
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Alternative nameTAME Hydrochloride
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