Angiostatin K1-3, human recombinant
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Catalog number4920-1000
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Price:
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Size1 mg
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SynonymsAngiostatin K1-3, Angiostatin Kringles 1-4
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Alternative_namesAngiostatin K1-4, Angiostatin Kringles 1-4, plasminogen
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DescriptionA specific inhibitor of endothelial cell growth and angiogenesis
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RecombinantYes
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SourceE. coli
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Purity by SDS PAGE≥95%
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AssaySDS-PAGE
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Purity≥95%
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Biological activityThe activity is assayed on anti-proliferation and anti-migration of endothelial cells in vitro and anti-angiogenesis in vivo. The specific activity of anti-migration of endothelial cells in vitro is 0.55×10⁵ Units/mg.
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Results0.55×10⁵ Units/mg.
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Molecular Weight30.0 kDa
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Storage Temp-20°C
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ShippingGel pack
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Shelf Life12 months
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AppearanceLyophilized protein
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Physical form descriptionFrom 20 mM Sodium Acetate, pH 5.5, 4% mannitol
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Reconstitution InstructionsReconstitute in sterile distilled H₂O or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml.
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Background InformationAng K1-3 is a single, non-glycosylated polypeptide chain containing 259 amino acids. It represents a proteolytic fragment of plasminogen containing the first three kringle structures. A specific inhibitor of endothelial cell growth and angiogenesis. Displays increased inhibitory activity (ED₅₀ =70 nM) relative to kringles 1-4 (ED₅₀ = 135 nM). Ang K1-3 reduces endothelial cell proliferation and acts as a potent inhibitor of angiogenesis and tumor growth.
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HandlingCentrifuge the vial prior to opening.
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UsageFor Research Use Only! Not to be used in humans
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PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional sourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolKRT13, KCNG1, COLEC11, MIR1302-3, MIR509-3, MIR7-3, PIRC12, PIRC14
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Short nameAngiostatin K1-3, recombinant
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TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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SpeciesHuman, Humans
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Alternative nameAngiostatin K1-3, H. sapiens Rec.
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Alternative techniquerec
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Gene info
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Identity
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Gene
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Long gene namekeratin 13
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Synonyms gene name
- keratin 13, type I
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Synonyms
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Synonyms name
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Locus
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Discovery year1990-11-05
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Keratins, type I
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namepotassium voltage-gated channel modifier subfamily G member 1
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Synonyms gene
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Synonyms gene name
- potassium voltage-gated channel, subfamily G, member 1
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Synonyms
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GenBank acession
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Locus
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Discovery year1993-03-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Potassium voltage-gated channels
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namecollectin subfamily member 11
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2001-11-20
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Entrez gene record
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RefSeq identity
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Classification
- Collectins
- C-type lectin domain containing
- Complement system activation components
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namemicroRNA 1302-3
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Synonyms gene
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Synonyms
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Locus
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Discovery year2008-11-03
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR1302 family
Gene info
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Identity
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Gene
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Long gene namemicroRNA 509-3
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Synonyms gene
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Synonyms
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Locus
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Discovery year2007-10-24
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR506 family
Gene info
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Identity
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Gene
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Long gene namemicroRNA 7-3
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Synonyms gene
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Synonyms
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Locus
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Discovery year2004-04-23
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR7 family
Gene info
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Identity
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Gene
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Long gene namepiwi-interacting RNA cluster 12
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Locus
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Discovery year2009-11-05
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Entrez gene record
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Pubmed identfication
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Classification
- Piwi-interacting RNA clusters
Gene info
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Identity
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Gene
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Long gene namepiwi-interacting RNA cluster 14
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Locus
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Discovery year2009-11-05
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Entrez gene record
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Pubmed identfication
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Classification
- Piwi-interacting RNA clusters
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data