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Synonyms
Angiostatin K1-4, Angiostatin Kringles 1-4
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Alternative_names
Angiostatin K1-4, Angiostatin Kringles 1-4, plasminogen
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Description
An endogenous angiogenesis inhibitor
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Recombinant
No
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Source
Human Plasma
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Purity by SDS PAGE
≥95%
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Assay
SDS-PAGE
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Molecular Weight
50.0 kDa
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Storage Temp
-80°C
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Shipping
Dry ice
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Shelf Life
12 months
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Concentration
7.0-8.0 mg/ml
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Appearance
Liquid
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Physical form description
In 20 mM HEPES, 150 mM NaCl, pH 7.4
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Background Information
Angiostatin is a proteolytic fragment of plasminogen constituting kringles 1 - 4. It is a potent angiogenesis inhibitor and the inhibition of angiogenesis by angiostatin is directly related to inhibiting the proliferation of endothelial cells. Human Angiostatin significantly inhibits bFGF-induced endothelial cell proliferation and migration at concentrations ranging from 300 nM – 1.0 µM.
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Handling
Centrifuge the vial prior to opening.
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Usage
For Research Use Only! Not to be used in humans
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.