VAV3 Polyclonal Antibody

• Catalog number
  CAC07952
• Price
  Please ask
• Size
  50 μg

• Other name
  Guanine nucleotide exchange factor VAV3,VAV-3,VAV3
• Immunogen
  Recombinant Human Guanine nucleotide exchange factor VAV3 protein (562-674AA)
• Verified reactivity
  Human, Mouse, Rat
• Verified applications
  ELISA,WB,IHC. Recommended dilution:WB:1:500-1:5000,IHC:1:20-1:200
• Raised in
  Rabbit
• Clonality
  Polyclonal
• Protein number
  Q9UKW4
• Gene number
  Please refer to GenBank
• NCBI number
  Please refer to NCBI
• Purity
  Protein G purified, >95%
• Storage recommendation
  Aliquot and store at -20°C. Minimize freezing and thawing.
• Use before
  1 year
• Shipping requirements
  Blue ice
• Estimated production time
  3-7 business days
• Supplementary information
  Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity).
• Notes
  For research use only. Not for diagnostic procedures.
• Hyperlink
• Properties
  If you buy Antibodies supplied by bioma they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Group
  Polyclonals and antibodies
• About
  Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
• French translation
  anticorps

• Gene target
  VAV3  
• Gene symbol
  VAV3, VAV3-AS1
• Short name
  VAV3 Polyclonal Antibody
• Technique
  Polyclonal, Antibody, antibodies against human proteins, antibodies for, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
• Label
  Unconjugated
• Alternative name
  vav 3 guanine nucleotide exchange factor polyclonal (antibody to-)
• Alternative technique
  polyclonals, antibodies
• Alternative to gene target
  vav 3 guanine nucleotide exchange factor, VAV3 and IDBG-100649 and ENSG00000134215 and 10451, metal ion binding, Plasma membranes, Vav3 and IDBG-188386 and ENSMUSG00000033721 and 57257, VAV3 and IDBG-635847 and ENSBTAG00000031575 and 521961

Gene info

• Identity
  HGNC:12659
• Gene
  VAV3
• Long gene name
  vav guanine nucleotide exchange factor 3
• Synonyms gene name
  • vav 3 oncogene
  • vav 3 guanine nucleotide exchange factor
• GenBank acession
  • AF118886
• Locus
  1p13.3
• Discovery year
  1999-07-07
• Entrez gene record
  10451
• RefSeq identity
  • NM_006113
• Classification
  • Dbl family Rho GEFs
  • Pleckstrin homology domain containing
  • MicroRNA protein coding host genes
  • SH2 domain containing
• VEGA ID
  OTTHUMG00000010995

Gene info

• Identity
  HGNC:40608
• Gene
  VAV3-AS1
• Long gene name
  VAV3 antisense RNA 1
• Synonyms gene name
  • VAV3 antisense RNA 1 (non-protein coding)
• GenBank acession
  • AA425131
  • BG193383
• Locus
  1p13.3
• Discovery year
  2012-02-24
• Entrez gene record
  100873946
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000010994

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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