VAV3 Antibody
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Catalog numberbs-4286R
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PricePlease ask
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Size0.1ml
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Long nameVAV3 Primary Polyclonal Antibody
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Also known asVAV3 PAb
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CategoryPrimary Antibodies
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ConjugationUnconjugated
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Target AntigenVAV3
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SpecificityThis is a highly specific antibody against VAV3.
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Modification sNone
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Modification site sUnmodified antibody
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ClonalityPolyclonal antibody
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Clone numberPolyclonal antibody
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Concentration1ug per 1ul
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Immunogen range710-760/847
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Subcellular locationCytoplasm
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SourceKLH conjugated synthetic peptide derived from mouse VAV3
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Gene ID number57257
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Swiss ProtQ9R0C8
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Tested ApplicationsWB, IHC-P, IF(IHC-P)
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Recommended dilutionsWB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
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Cross reactivityHuman, Mouse, Rat
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Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the target antigenExchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases (By similarity). Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3-mediated adhesion. Does not affect integrin beta-1-mediated adhesion.
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Purification methodThis antibody was purified via Protein A.
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Storage conditionsKeep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
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Synonym namesIdd18.1; AA986410; A530094I06Rik; Guanine nucleotide exchange factor VAV3; VAV-3; Vav3
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PropertiesIf you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolVAV3, VAV3-AS1
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Short nameAnti-VAV3
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TechniqueAntibody, antibodies against human proteins, antibodies for
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HostRabbit (Oryctolagus cuniculus)
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IsotypeImmunoglobulin G (IgG)
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Alternative nameVAV3 Polyclonal Antibody
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Alternative techniqueantibodies
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Alternative to gene targetvav 3 guanine nucleotide exchange factor, VAV3 and IDBG-100649 and ENSG00000134215 and 10451, metal ion binding, Plasma membranes, Vav3 and IDBG-188386 and ENSMUSG00000033721 and 57257, VAV3 and IDBG-635847 and ENSBTAG00000031575 and 521961
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Gene info
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Identity
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Gene
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Long gene namevav guanine nucleotide exchange factor 3
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Synonyms gene name
- vav 3 oncogene
- vav 3 guanine nucleotide exchange factor
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GenBank acession
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Locus
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Discovery year1999-07-07
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Entrez gene record
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RefSeq identity
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Classification
- Dbl family Rho GEFs
- Pleckstrin homology domain containing
- MicroRNA protein coding host genes
- SH2 domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameVAV3 antisense RNA 1
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Synonyms gene name
- VAV3 antisense RNA 1 (non-protein coding)
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GenBank acession
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Locus
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Discovery year2012-02-24
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Entrez gene record
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Classification
- Antisense RNAs
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data