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Alternative_name
N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride
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Description
A cell-permeable, reversible, and selective Rac1 inhibitor; inhibiting Rac1 activation by the Rac-specific guanine nucleotide exchange factors (GEFs) TrioN and Tiam 1 (IC₅₀ = 50 μM) without affecting the closely related GTPases, Cdc42, and RhoA activation. NSC 23766 has been used to investigate the role of Rac1 in such diverse cellular functions as stem cell mobilization, epithelial cell migration, angiogenesis, leukemia cell migration and growth, etc.
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CAS Number
733767-34-5
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₂₄H₃₅N₇.3HCl
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Molecular Weight
530.97
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Cell Permeable
Yes
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Purity
≥98% by HPLC
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Solubilities
Water (100 mM)
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Handling
Protect from light and moisture
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Tag Line
A potent Rac1 inhibitor
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
36 months
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PubChem CID
16759159
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SMILES
CCN(CC)CCCC(C)NC1=NC(=CC(=N1)NC2=CC3=C(C=C2)N=C(C=C3N)C)C.Cl.Cl.Cl
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InChi
InChI=1S/C24H35N7.3ClH/c1-6-31(7-2)12-8-9-16(3)27-24-28-18(5)14-23(30- 24)29-19-10-11-22-20(15-19)21(25)13-17(4)26-22;;;/h10-11,13-16H,6-9, 12H2,1-5H3,(H2,25,26)(H2,27,28,29,30);3*1H
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InChi Key
CPUHORIUXPQCHW-UHFFFAOYSA-N
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MSDS Available
Yes