Stat3 Activation Inhibitor, SPI
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Catalog number1813-2
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PricePlease ask
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Size2 mg
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Alternative_nameFISKERERAILSTKPPGTFLLRFSESSK
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DescriptionCell-permeable. A potent and selective inhibitor of Stat3 SH2 domain:pTyr interactions; also disrupts the binding of Stat3 to the IL-6R/gp130 peptide, GpYLPQTVNH₂ and induces antitumor effects in vitro.
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Structure AvailableNo
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Peptide sequenceH-Phe-Ile-Ser-Lys-Glu-Arg-Glu-Arg-Ala-Ile-Leu-Ser-Thr-Lys-Pro-Pro-Gly-Thr-Phe-Leu-Leu-Arg-Phe-Ser-Glu-Ser-Ser-Lys-OH
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Salt FormYes
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Molecular FormulaC₁₄₆H₂₃₈N₄₀O₄₂.C₂HF₃O₂
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Molecular Weight3225.74. 114.02
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Cell PermeableYes
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Purity≥95% by HPLC
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SolubilitiesH₂O
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HandlingProtect from air and moisture
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Tag LineA Stat3 activation inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life24 months
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SMILESN/A
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InChiN/A
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InChi KeyN/A
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MSDS AvailableYes
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolSPIB, SPI1, SPIC
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Short nameStat3 Activation Inhibitor, SPI
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Techniqueactivation
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Alternative namesignal transducer and activator on transcription 3 (acute-phase response factor) Activation suppressor, SPI
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Alternative to gene targetsignal transducer and activator of transcription 3 (acute-phase response factor), ADMIO and APRF and HIES, STAT3 and IDBG-50702 and ENSG00000168610 and 6774, protein dimerization activity, nuclei, Stat3 and IDBG-211637 and ENSMUSG00000004040 and 20848, STAT3 and IDBG-640197 and ENSBTAG00000021523 and 101910056,508541
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Gene info
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Identity
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Gene
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Long gene nameSpi-B transcription factor
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Synonyms gene name
- Spi-B transcription factor (Spi-1/PU.1 related)
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Synonyms
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Locus
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Discovery year1994-12-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- ETS transcription factor family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameSpi-1 proto-oncogene
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Synonyms gene name
- spleen focus forming virus (SFFV) proviral integration oncogene
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1988-07-04
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- ETS transcription factor family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameSpi-C transcription factor
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Synonyms gene name
- Spi-C transcription factor (Spi-1/PU.1 related)
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Synonyms
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GenBank acession
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Locus
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Discovery year2004-03-18
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- ETS transcription factor family
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VEGA ID