Stat3 Activation Inhibitor, SPI

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Description

Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

Gene target

Stat3 Activation Inhibitor SPI
Gene symbol

SPIB, SPI1, SPIC
Short name

Stat3 Activation Inhibitor, SPI
Technique

activation
Alternative name

signal transducer and activator on transcription 3 (acute-phase response factor) Activation suppressor, SPI
Alternative to gene target

signal transducer and activator of transcription 3 (acute-phase response factor), ADMIO and APRF and HIES, STAT3 and IDBG-50702 and ENSG00000168610 and 6774, protein dimerization activity, nuclei, Stat3 and IDBG-211637 and ENSMUSG00000004040 and 20848, STAT3 and IDBG-640197 and ENSBTAG00000021523 and 101910056,508541

Identity

HGNC:11241
Gene

SPI1
Long gene name

Spi-1 proto-oncogene
Synonyms gene name
- spleen focus forming virus (SFFV) proviral integration oncogene
Synonyms
- PU.1
- SPI-A
- OF
- SFPI1
- SPI-1
Synonyms name
- hematopoietic transcription factor PU.1
- 31 kDa transforming protein
GenBank acession
- X52056
Locus

11p11.2
Discovery year

1988-07-04
Entrez gene record

6688
Pubmed identfication
- 1693183
RefSeq identity
- NM_003120
Classification
- ETS transcription factor family
VEGA ID

OTTHUMG00000150150