anti-PMAIP1 Antibody
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Catalog number48-540
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Price:
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Size0.05 mg
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Gene infoRecently, a BH-3 only member of the Bcl-2 family have been identified in human and mouse and designated as Noxa (for damage). The expression of the Noxa gene involves direct activation of its promoter by p53. Increased expression of Noxa protein occurs in normal thymocytes but not in p53-deficient thymocytes. Noxa cDNA codes for a 103-amino acid protein. The coimmunoprecipitation data suggest that Noxa protein may interact with proteins belonging to the Bcl-2 family, such as, Bcl-XL and Mcl-1. Oda et al have also shown that blocking the endogenous Noxa induction results in the suppression of apoptosis. Treatment of cells with Noxa antisense oligonucleotides blocks radiation-induced apoptosis suggesting that Noxa may represent a mediator of p53-dependent apoptosis.
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Gene namesPMAIP1, NOXA, PMA-induced protein 1, Protein Noxa, APR
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Antibodie s labelunlabelled serum
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PurityProtein G Column
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Ab raised inRabbit
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TypePolyclonal
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ImmunoglobulinIgG
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AntigenPMAIP1 antibody was made against amino acids 51 - 66 and 75-90 of PMAIP1 (Mouse).
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Immuno applicationWestern Blot, immuno-histo-chemistry
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Antibody advicePMAimmunoprecipitation1 antibody can be used in immunohistochemistry starting at 20 ug/mL, and flow cytometry.
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Suspention pH azidePBS, 0.05% BSA, 0.05% sodium azide.
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Keep atPMAIP1 antibody should be stored long term (months) at -20 grades C and short term (weeks) at 4 grades C. As with all antibodies avoid freeze/thaw cycles.
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Works withHuman, Mouse, Rat
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Omim nr6919841
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Ncbi nrQ13794
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Vial with antibodyin solution
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NCBI GENE nr5366
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GENE symbolPMAIP1
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Antigene namephorbol-12-myristate-13-acetate-induced protein 1
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SourceHomo sapiens
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Protein nrQ13794
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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PropertiesIf you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolPMAIP1
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Short nameanti-PMAIP1 Antibody
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TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative nameAntibody tophorbol-12-myristate-13-acetate-induced protein 1 (antibody to-)
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Alternative techniqueantibodies
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Alternative to gene targetphorbol-12-myristate-13-acetate-induced protein 1, APR and NOXA, PMAIP1 and IDBG-4142 and ENSG00000141682 and 5366, protein binding, nuclei, Pmaip1 and IDBG-155006 and ENSMUSG00000024521 and 58801
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Gene info
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Identity
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Gene
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Long gene namephorbol-12-myristate-13-acetate-induced protein 1
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Synonyms
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GenBank acession
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Locus
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Discovery year1991-08-12
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- BCL2 homology region 3 (BH3) only
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data