Recombinant Mouse Scavenger Receptor B2/SR-B2/LIMPII/CD36L2 Protein(C-Fc)

• Catalog number
  PKSM041135-10µg
• Price
  Please ask
• Size
  10µg

• Synonym
  Lysosome membrane protein 2; 85 kDa lysosomal membrane sialoglycoprotein; LGP85; Lysosome membrane protein II; LIMP II; Scavenger receptor class B member 2; Scarb2
• Activity
  NA
• Sequence
  Arg27-Thr432
• Fusion tag
  C-Fc
• Accession
  O35114
• Expressed Host
  Human Cells
• Shipping
  The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
• Purity
  ＞95% as determined by reducing SDS-PAGE.
• Stability and Storage
  Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months
• Mol Mass
  47.1 kDa
• AP Mol Mass
  65-90 kDa
• Formulation
  Lyophilized from a 0.2 μm filtered solution of 50mM Tris-Citrate, 0.3M NaCl, pH6.5.
• Background
  Lysosome membrane protein II (LIMPII)，also known as SCARB2, is a type III multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far examined. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is identified as a receptor for EV71 (human enterovirus species A, Enterovirus 71) and CVA16 (coxsackievirus A16) which are most frequently associated with hand, foot and mouth disease (HFMD). Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. In addition, LIMPII also has been shown to bind thrombospondin-1, may contribute to the pro-adhesive changes of activated platelets during coagulation, and inflammation.
• Technical data
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• Description
  The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Scavenger   Receptor   B2/SR-B2/LIMPII/CD36L2   Protein   C-Fc  
• Gene symbol
  SCARB2, MSR1, SNAR-B2, MEGF10, PCDHGB2, MARCO, MED20, SRPRB, SIGMAR1, SNCG
• Short name
  Recombinant Mouse Scavenger Receptor B2/SR-B2/LIMPII/CD36L2 Protein(C-Fc)
• Technique
  Recombinant, Mouse, FC, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Host
  mouse
• Species
  Mouse, Mouses
• Alternative name
  Rec. Mouse Scavenger Receptor B2/SR-B2/LIMPII/CD36L2 Protein(C-fragment c)
• Alternative technique
  rec, murine

Gene info

• Identity
  HGNC:1665
• Gene
  SCARB2
• Long gene name
  scavenger receptor class B member 2
• Synonyms gene
  • CD36L2
• Synonyms gene name
  • CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II)
• Synonyms
  • HLGP85
  • LIMPII
  • SR-BII
  • LIMP-2
• Synonyms name
  • lysosome membrane protein 2
  • lysosomal integral membrane protein II
• GenBank acession
  • D12676
• Locus
  4q21.1
• Discovery year
  1994-09-07
• Entrez gene record
  950
• Pubmed identfication
  • 1374238
• RefSeq identity
  • NM_005506
• Classification
  • Scavenger receptors
• VEGA ID
  OTTHUMG00000130099

Gene info

• Identity
  HGNC:7376
• Gene
  MSR1
• Long gene name
  macrophage scavenger receptor 1
• Synonyms
  • SCARA1
  • CD204
  • SR-AI
  • SR-AII
  • SR-AIII
  • SR-A
• GenBank acession
  • D13263
• Locus
  8p22
• Discovery year
  1991-08-07
• Pubmed identfication
  • 2251254
• Classification
  • CD molecules
  • Scavenger receptors
  • Scavenger receptor cysteine rich domain containing
• VEGA ID
  OTTHUMG00000094809

Gene info

• Identity
  HGNC:34318
• Gene
  SNAR-B2
• Long gene name
  small NF90 (ILF3) associated RNA B2
• Synonyms gene name
  • small ILF3/NF90-associated RNA B2
• GenBank acession
  • EU071065
• Locus
  19q13.33
• Discovery year
  2008-07-03
• Entrez gene record
  100170217
• Pubmed identfication
  • 17855395
• RefSeq identity
  • NR_024230
• Classification
  • Small NF90 (ILF3) associated RNAs

Gene info

• Identity
  HGNC:29634
• Gene
  MEGF10
• Long gene name
  multiple EGF like domains 10
• Synonyms gene name
  • multiple EGF-like-domains 10
• Synonyms
  • KIAA1780
  • SR-F3
• GenBank acession
  • AK021631
• Locus
  5q23.2
• Discovery year
  2006-03-31
• Entrez gene record
  84466
• Pubmed identfication
  • 11347906
  • 27170117
• RefSeq identity
  • NM_032446
• Classification
  • Scavenger receptors
• VEGA ID
  OTTHUMG00000128984

Gene info

• Identity
  HGNC:8709
• Gene
  PCDHGB2
• Long gene name
  protocadherin gamma subfamily B, 2
• Synonyms
  • PCDH-GAMMA-B2
• GenBank acession
  • AF152331
• Locus
  5q31
• Discovery year
  2000-06-28
• Entrez gene record
  56103
• Pubmed identfication
  • 10380929
• RefSeq identity
  • NM_018923
• Classification
  • Clustered protocadherins
• VEGA ID
  OTTHUMG00000163682

Gene info

• Identity
  HGNC:6895
• Gene
  MARCO
• Long gene name
  macrophage receptor with collagenous structure
• Synonyms
  • SCARA2
  • SR-A6
• Synonyms name
  • scavenger receptor class A, member 2
• GenBank acession
  • AF035819
• Locus
  2q14.2
• Discovery year
  1998-11-26
• Entrez gene record
  8685
• Pubmed identfication
  • 9468508
  • 7867067
  • 10331948
• RefSeq identity
  • NM_006770
• Classification
  • Scavenger receptors
  • Scavenger receptor cysteine rich domain containing
• VEGA ID
  OTTHUMG00000131400

Gene info

• Identity
  HGNC:16840
• Gene
  MED20
• Long gene name
  mediator complex subunit 20
• Synonyms gene
  • TRFP
• Synonyms gene name
  • Trf (TATA binding protein-related factor)-proximal homolog (Drosophila)
• Synonyms
  • DKFZp586D2223
  • PRO0213
  • SRB2
• GenBank acession
  • AF097725
• Locus
  6p21.1
• Discovery year
  2003-08-26
• Entrez gene record
  9477
• Pubmed identfication
  • 9933582
  • 15175163
• RefSeq identity
  • NM_004275
• Classification
  • Mediator complex
• VEGA ID
  OTTHUMG00000014689

Gene info

• Identity
  HGNC:24085
• Gene
  SRPRB
• Long gene name
  SRP receptor subunit beta
• Synonyms gene name
  • signal recognition particle receptor, B subunit
• Synonyms
  • APMCF1
  • SR-beta
• GenBank acession
  • AK075531
• Locus
  3q22.1
• Discovery year
  2004-01-29
• Entrez gene record
  58477
• Pubmed identfication
  • 7844142
  • 10859309
• VEGA ID
  OTTHUMG00000159753

Gene info

• Identity
  HGNC:8157
• Gene
  SIGMAR1
• Long gene name
  sigma non-opioid intracellular receptor 1
• Synonyms gene
  • OPRS1
• Synonyms gene name
  • opioid receptor, sigma 1
• Synonyms
  • SR-BP1
• GenBank acession
  • BC004899
• Locus
  9p13.3
• Discovery year
  1993-03-11
• Entrez gene record
  10280
• Pubmed identfication
  • 8954936
  • 9453537
• RefSeq identity
  • NM_005866
• VEGA ID
  OTTHUMG00000019829

Gene info

• Identity
  HGNC:11141
• Gene
  SNCG
• Long gene name
  synuclein gamma
• Synonyms
  • BCSG1
  • SR
  • persyn
• Synonyms name
  • synoretin
  • breast cancer-specific gene 1
  • ɣ-synuclein
• GenBank acession
  • AF044311
• Locus
  10q23.2
• Discovery year
  1998-04-07
• Entrez gene record
  6623
• Pubmed identfication
  • 9044857
  • 9700196
• VEGA ID
  OTTHUMG00000018656
• Locus Specific Databases
  • ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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