Thomsen-Friedenreich Antigen /CD176 (Pan Carcinoma Marker) Mouse Monoclonal Antibody

• Catalog number
  MBS439111
• Price
  Please ask
• Size
  5x0.1 mg (Without BSA at 1mg/mL)

• Products_type
  Antibody
• Products_short_name
  [Thomsen-Friedenreich Antigen /CD176]
• Products_name_syn
  [T-F Antigen; TF Antigen; Asialoglycophorin; pan-carcinoma marker; CD176]
• Clonality
  Monoclonal
• Clone
  [A68-B/A11]
• Reactivity
  Human, Mouse, Rat
• Specificity
  Recognizes a disaccharide epitope, Gal1-3GalNAc, of Thomsen-Friedenreich (TF) antigen. It is specific for both anomeric forms of the disaccharide (TF and TF, including related structures on the glycolipid) and shows no cross-reactivity with sialylated glycophorin. The Thomsen-Friedenreich antigen acts as an oncofetal antigen, with low expression in normal adult tissues but increasing to fetal levels of expression in hyperplasia or malignancy. It is considered as a pan-carcinoma marker. This MAb is capable to agglutinate desialylated red blood cells. During metastasis, the ability of malignant cells to form multicellular aggregates via homotypic or heterotypic aggregation and their adhesion to the endothelium are critical. The tumor-associated carbohydrate Thomsen-Friedenreich antigen (Gal-GalNAc) is involved in tumor cell adhesion and tissue invasion. It also causes an immune response, and overexpression of the antigen causes cancer cells to be more sensitive to natural killer cell lysis. The Thomsen-Friedenreich antigen is suppressed in normal healthy cells and represents one of the few chemically well-defined antigens associated with tumor malignancy. The presence of the Thomsen-Friedenreich antigen on the surface of cancer cells may result from a divergence from the normal pathway for O-linked glycosylation in these cells, most likely caused by inappropriate localization of the enzymes involved in synthesis of the disaccharide.
• Form
  200ug/ml of Ab purified from Bioreactor Concentrate. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. (Also available WITHOUT BSA & azide at 1.0mg/ml.)
• Storage_stability
  Antibody with azide - store at 2 to 8°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Tested_application
  Immunofluorescence (IF), Immunohistology (Formalin-fixed)
• Properties
  If you buy Antibodies supplied by MyBioSource they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Description
  Antigens are peptides or recombinant or native dependent on the production method.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• French translation
  anticorps

• Gene target
  Thomsen-Friedenreich   CD176   Pan   Carcinoma   Monoclonal  
• Short name
  Thomsen-Friedenreich Antigen /CD176 (Pan Carcinoma ) Mouse Monoclonal Antibody
• Technique
  Mouse monoclonal, Antibody, antigen, Mouse, antibodies against human proteins, antibodies for, antigenes, Component cell markers and DNA bp. markers are genetic markers er genes or DNA sequences with a known location on a chromosome that can be used to identify individuals or species. Protein markers in kDA. Monoclonals or monoclonal antibodies, mouses, mouse monoclonals
• Host
  Mouse, Murine monoclonal antibodies or Mabs are often conjugated and the isotype is IgG.
• Isotype
  IgM, kappa
• Species
  Mouse, Mouses
• Alternative name
  Thomsen-Friedenreich protein /CD176 (Pan Carcinoma detection labelled) Mouse monoclonal (antibody to-)
• Alternative technique
  antibodies, antigenes, murine
• Tissue
  carcinoma

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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