anti- UHRF1 antibody

• Catalog number
  FNab09245
• Price
  Please ask
• Size
  2X100μg

• Form
  liquid
• Purification
  Immunogen affinity purified
• Purity
  ≥95% as determined by SDS-PAGE
• Storage
  PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
• Background
  This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.
• Immunogen
  ubiquitin-like with PHD and ring finger domains 1
• Synonyms
  FLJ21925, hNP95, HuNp95, ICBP90, Nuclear protein 95, RING finger protein 106, RNF106, Transcription factor ICBP90, UHRF1
• Calculated MW
  110 kDa
• Uniprot ID
  Q96T88
• Specificity
  Human
• Tested Application
  ELISA, WB, IHC, IF
• Recommended dilution
  WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:20 - 1:50
• Image4
  HeLa cells were subjected to SDS PAGE followed by western blot with FNab09245(UHRF1 antibody) at dilution of 1:1000
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• Properties
  If you buy Antibodies supplied by FineTest they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  UHRF1  
• Gene symbol
  UHRF1
• Short name
  anti- UHRF1 antibody
• Technique
  Antibody, anti, antibody to, antibodies against human proteins, antibodies for
• Host
  Rabbit
• Isotype
  IgG
• Alternative name
  antibody to- UHRF1 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:12556
• Gene
  UHRF1
• Long gene name
  ubiquitin like with PHD and ring finger domains 1
• Synonyms
  • ICBP90
  • Np95
  • FLJ21925
  • RNF106
  • TDRD22
• GenBank acession
  • AF129507
• Locus
  19p13.3
• Discovery year
  2000-03-15
• Entrez gene record
  29128
• Pubmed identfication
  • 10646863
  • 28100769
• RefSeq identity
  • NM_001048201
• Classification
  • MicroRNA protein coding host genes
  • Ring finger proteins
  • PHD finger proteins
  • Tudor domain containing
• VEGA ID
  OTTHUMG00000180251

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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