Anti-NGFR Antibody

• Catalog number
  A1650-100
• Price
  Please ask
• Size
  100 µl

• Antibody Target
  NGFR
• Target Alternative Name
  TNFRSF16; Tumor necrosis factor receptor superfamily member 16; Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD; CD271
• Antibody Type
  Polyclonal
• Species Reactivities
  Human, Mouse, Rat
• Immunogen Sequence
  A synthesized peptide derived from human NGFR
• Accession
  P08138
• Gene Id
  4804
• Appearance
  Colorless liquid
• Form
  Liquid
• Concentration
  1 mg/ml
• Formulation
  In phosphate buffered saline , pH 7.4, 150 mM, NaCl, 0.02% sodium azide and 50% glycerol.
• Purification
  Affinity purified
• Application
  WB, IHC, IF
• Positive Control
  WB: Mouse brain lysate, IF: HepG2 cells, IHC: human glioma tissue
• Application And Usages
  WB 1:500-1:2000 IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA (peptide) 1:20000-1:40000
• Description
  The p75 neurotrophin receptor (p75NTR), a member of the TNF receptor superfamily, is distinguished by multiple cysteine-rich ligand-binding domains, a single transmembrane sequence and a noncatalytic cytoplasmic domain. p75NTR displays paradoxical functions when acting alone or with other receptor proteins. Working in concert with Trk receptors, p75NTR recognizes neurotrophins and transmits trophic signals into the cell. Both p75NTR and TrkA are required to activate PI3K-Akt signaling, while TrkA can individually activate the MAP kinase pathway. In contrast, p75NTR, possibly through JNK, ensures appropriate apoptosis of injured neurons and improperly targeted neonatal neurons.The p75NTR protein undergoes sequential cleavage similar to APP and Notch. First, α-secretase removes the p75NTR ectodomain, eliminating ligand-mediated signaling. At this point, the membrane-tethered cleavage product can still fine-tune Trk-mediated trophic actions.
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Not Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• FACS Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Dot Blot Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Additional description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  NGFR  
• Gene symbol
  NGFR-AS1, NGFR
• Short name
  Anti-NGFR Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibody toNGFR (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  nerve growth factor receptor, CD271 and Gp80-LNGFR and p75(NTR) and p75NTR and TNFRSF16, NGFR and IDBG-57653 and ENSG00000064300 and 4804, nerve growth factor binding, nuclei, Ngfr and IDBG-209608 and ENSMUSG00000000120 and 18053, NGFR and IDBG-638806 and ENSBTAG00000020979 and 353110

Gene info

• Identity
  HGNC:55555
• Gene
  NGFR-AS1
• Long gene name
  NGFR antisense RNA 1
• Locus
  17q21.33
• Discovery year
  2021-04-07
• Entrez gene record
  100288866
• RefSeq identity
  • NR_103773
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:7809
• Gene
  NGFR
• Long gene name
  nerve growth factor receptor
• Synonyms gene name
  • nerve growth factor receptor (TNFR superfamily, member 16)
• Synonyms
  • TNFRSF16
  • CD271
  • p75NTR
• Synonyms name
  • low affinity nerve growth factor receptor
  • TNFR superfamily, member 16
• GenBank acession
  • M14764
• Locus
  17q21.33
• Discovery year
  2001-06-22
• Entrez gene record
  4804
• Pubmed identfication
  • 3022937
  • 3006050
• Classification
  • CD molecules
  • MicroRNA protein coding host genes
  • Tumor necrosis factor receptor superfamily
• VEGA ID
  OTTHUMG00000161495

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

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