Anti-COPA/alpha COP I (Polyclonal), ALEXA Fluor 594

• Catalog number
  GENTObs-12464R-A594
• Price
  Please ask
• Size
  100 microliters

• Type
  Conjugated Primary Antibody
• Conjugated with
  ALEXA FLUOR® 594
• Host organism
  Rabbit (Oryctolagus cuniculus)
• Target Protein Peptide
  COPA/alpha COP I
• Specificity
  This antibody reacts specifically with COPA/alpha COP I
• Modification
  No modification has been applied to this antibody
• Modification site
  None
• Clonality
  Polyclonal Antibody
• Clone
  Polyclonal Antibodies
• Concentration
  1ug per 1ul
• Subcellular locations
  N/A
• Antigen Source
  KLH conjugated synthetic peptide derived from human COPA/alpha COP I
• Gene ID
  1314
• Swiss Prot
  N/A
• Applications
  IF(IHC-P)
• Applications with corresponding dilutions
  IF(IHC-P)(1:50-200)
• Cross reactive species
  Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)
• Cross Reactive Species details
  No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
• Background information
  COPA (alpha-coat protein) is processed to produce Xenin. Xenin stimulates exocrine pancreatic secretion to affect small and large intestinal motility, and inhibits pentagastrin-stimulated secretion of acid. In the gut, Xenin interacts with the neurotensin receptor. Membrane and vesicular trafficking in the early secretory pathway are mediated by non-Clathrin COP (coat protein) I-coated vesicles. COPI-coated vesicles mediate retrograde transport from the Golgi back to the ER and intra-Golgi transport. The cytosolic precursor of the COPI coat, the heptameric coatomer complex, is composed of two subcomplexes. The first consists of the COPB, COPG, COPD and COPZ subunits (also known as b-, g-, d- and z-COP, respectively), which are distantly homologous to AP Clathrin adaptor subunits. The second consists of the COPA, b'-COP and COPE subunits (also known as a-COP, COPP and e-COP, respectively).
• Purification method
  Purified by Protein A.
• Storage
  Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
• Excitation emission
  590nm/617nm
• Synonyms
  Alpha coat protein; Alpha COP; Alpha COPI; AlphaCOP; Coatomer protein complex subunit alpha; Coatomer subunit alpha; COP A; COP I alpha; COPA; COPI alpha; FLJ26320; HEP COP; HEPCOP; Proxenin; Xenin; Xenopsin-related peptide; COPA_HUMAN.
• Also known as
  COPA/alpha COP I Polyclonal Antibody
• Other name
  Anti-COPA/alpha COP I Polyclonal
• Advisory
  Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
• Properties
  For facs or microscopy Alexa 1 conjugate.
• Conjugation
  Alexa Fluor, ALEXA FLUOR® 594
• Conjugated
  Alexa conjugate 1
• Description
  The Anti-COPA/alpha COP I is a α- or alpha protein sometimes glycoprotein present in blood. This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Group
  Polyclonals and antibodies
• About
  Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.

• Gene target
  COPA/alpha   COP  
• Gene symbol
  COPA, COPB2, COPG2, COPE, CARD16
• Short name
  Anti-COPA/alpha COP I
• Technique
  Polyclonal, anti-, anti, antibody to, antibodies, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 594
• Alternative name
  COPA/alpha COP I Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated
• Alternative technique
  polyclonals, antibodies

Gene info

• Identity
  HGNC:2230
• Gene
  COPA
• Long gene name
  COPI coat complex subunit alpha
• Synonyms gene name
  • coatomer protein complex, subunit alpha
• Synonyms
  • HEP-COP
• Synonyms name
  • proxenin
  • xenin
• GenBank acession
  • U24105
• Locus
  1q23.2
• Discovery year
  1996-11-15
• Entrez gene record
  1314
• Pubmed identfication
  • 8647451
• RefSeq identity
  • NM_004371
• Classification
  • WD repeat domain containing
  • COPI coat complex
  • Receptor ligands
• VEGA ID
  OTTHUMG00000033111
• Locus Specific Databases
  • LRG_1336

Gene info

• Identity
  HGNC:2232
• Gene
  COPB2
• Long gene name
  COPI coat complex subunit beta 2
• Synonyms gene name
  • coatomer protein complex, subunit beta 2 (beta prime)
  • coatomer protein complex subunit beta 2 (beta prime)
• Synonyms
  • beta'-COP
  • betaprime-COP
• Synonyms name
  • coatomer protein complex subunit beta prime
• GenBank acession
  • BC000326
• Locus
  3q23
• Discovery year
  1999-04-23
• Entrez gene record
  9276
• Pubmed identfication
  • 9858824
• RefSeq identity
  • NM_004766
• Classification
  • WD repeat domain containing
  • COPI coat complex
• VEGA ID
  OTTHUMG00000159959

Gene info

• Identity
  HGNC:2237
• Gene
  COPG2
• Long gene name
  COPI coat complex subunit gamma 2
• Synonyms gene name
  • coatomer protein complex, subunit gamma 2
• Synonyms
  • 2-COP
• Synonyms name
  • coat protein, nonclathrin, gamma-2-cop
• GenBank acession
  • AF157833
• Locus
  7q32.2
• Discovery year
  1999-12-17
• Entrez gene record
  26958
• Pubmed identfication
  • 10556286
  • 10995575
• RefSeq identity
  • NM_012133
• Classification
  • Clathrin/coatomer adaptor, adaptin-like, N-terminal domain containing
  • COPI coat complex
• VEGA ID
  OTTHUMG00000155364

Gene info

• Identity
  HGNC:2234
• Gene
  COPE
• Long gene name
  COPI coat complex subunit epsilon
• Synonyms gene name
  • coatomer protein complex, subunit epsilon
• Synonyms
  • epsilon-COP
• GenBank acession
  • AJ131182
• Locus
  19p13.11
• Discovery year
  1999-09-28
• Entrez gene record
  11316
• Pubmed identfication
  • 10469566
• RefSeq identity
  • NM_007263
• Classification
  • COPI coat complex
• VEGA ID
  OTTHUMG00000183052

Gene info

• Identity
  HGNC:33701
• Gene
  CARD16
• Long gene name
  caspase recruitment domain family member 16
• Synonyms gene name
  • caspase recruitment domain family, member 16
• Synonyms
  • COP1
  • COP
  • PSEUDO-ICE
  • LLID-114769
• Locus
  11q22.3
• Discovery year
  2008-09-15
• Entrez gene record
  114769
• Pubmed identfication
  • 11432859
  • 11536016
• Classification
  • Caspase recruitment domain containing
• VEGA ID
  OTTHUMG00000166157

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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