BMP-2, human recombinant

• Catalog number
  4577-1000
• Price
  Please ask
• Size
  1 mg

• Synonyms
  BMP-2, BMP2A, bone morphogenetic protein2
• Alternative_names
  BMP-2, BMP2A, bone morphogenetic protein2
• Description
  A protein involved in the hedgehog and TGF beta signaling pathway
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥98%
• Assay
  SDS-PAGE
• Purity
  ≥98%
• Biological activity
  The ED₅₀ as determined by the dose-dependent cytolysis of MC3T3-E1 cells is < 50 ng/ml.
• Results
  < 50 ng/ml
• Molecular Weight
  26.0 kDa
• Storage Temp
  -20°C
• Shipping
  Gel pack
• Shelf Life
  12 months
• Appearance
  Lyophilized protein
• Physical form description
  Lyophilized without additives
• Reconstitution Instructions
  Reconstitute to a concentration of 0.1-1.0 mg/ml in H₂O containing BSA (50 ug BSA per 1 ug of protein). This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.
• Background Information
  BMPs (bone morphogenetic proteins) belong to the TGF-β superfamily of structurally related signaling proteins. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. In addition to its osteogenic activity, BMP-2 also plays an important role in cardiac morphogenesis. BMP-2 is expressed in a variety of tissues such as lung, spleen, brain, liver, prostate ovary, and small intestine. Recombinant human BMP-2 is a 26 kDa homodimeric protein consisting of two 115 amino acid polypeptide chains
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  BMP-2  
• Gene symbol
  BMP2, GDF11, GDF10, GDF2, BMP1, MIR1289-2, MIR521-2, MIR509-2, MIR512-2, MIR7-2
• Short name
  BMP-2, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  BMP-2, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:1069
• Gene
  BMP2
• Long gene name
  bone morphogenetic protein 2
• Synonyms gene
  • BMP2A
• Locus
  20p12.3
• Discovery year
  1990-06-11
• Entrez gene record
  650
• Pubmed identfication
  • 2376592
• Classification
  • Bone morphogenetic proteins
• VEGA ID
  OTTHUMG00000031833

Gene info

• Identity
  HGNC:4216
• Gene
  GDF11
• Long gene name
  growth differentiation factor 11
• Synonyms
  • BMP-11
  • BMP11
• GenBank acession
  • AF100907
• Locus
  12q13.2
• Discovery year
  1999-12-02
• Entrez gene record
  10220
• Pubmed identfication
  • 15988002
• Classification
  • Transforming growth factor beta superfamily
• VEGA ID
  OTTHUMG00000170188

Gene info

• Identity
  HGNC:4215
• Gene
  GDF10
• Long gene name
  growth differentiation factor 10
• Synonyms
  • BMP-3b
• GenBank acession
  • L42113
• Locus
  10q11.22
• Discovery year
  1997-09-12
• Entrez gene record
  2662
• Pubmed identfication
  • 8679252
• RefSeq identity
  • NM_004962
• Classification
  • Transforming growth factor beta superfamily
• VEGA ID
  OTTHUMG00000188319

Gene info

• Identity
  HGNC:4217
• Gene
  GDF2
• Long gene name
  growth differentiation factor 2
• Synonyms
  • BMP-9
  • BMP9
• GenBank acession
  • AF156891
• Locus
  10q11.22
• Discovery year
  1997-09-12
• Entrez gene record
  2658
• Pubmed identfication
  • 10849432
• RefSeq identity
  • NM_016204
• Classification
  • Transforming growth factor beta superfamily
• VEGA ID
  OTTHUMG00000188320

Gene info

• Identity
  HGNC:1067
• Gene
  BMP1
• Long gene name
  bone morphogenetic protein 1
• Synonyms gene
  • PCOLC
• Synonyms gene name
  • procollagen C-endopeptidase
• Synonyms
  • BMP-1
• Synonyms name
  • procollagen C-endopeptidase
  • tolloid-like
• Locus
  8p21.3
• Discovery year
  1990-06-11
• Entrez gene record
  649
• Pubmed identfication
  • 2004778
• RefSeq identity
  • NM_006132
• Classification
  • Bone morphogenetic proteins
  • Astacins
• VEGA ID
  OTTHUMG00000097761

Gene info

• Identity
  HGNC:35282
• Gene
  MIR1289-2
• Long gene name
  microRNA 1289-2
• Synonyms gene
  • MIRN1289-2
• Synonyms
  • hsa-mir-1289-2
• Locus
  5q31.1
• Discovery year
  2008-11-03
• Entrez gene record
  100302134
• RefSeq identity
  • NR_031621
• Classification
  • MicroRNA MIR1289 family

Gene info

• Identity
  HGNC:32113
• Gene
  MIR521-2
• Long gene name
  microRNA 521-2
• Synonyms gene
  • MIRN521-2
• Synonyms
  • hsa-mir-521-2
• Locus
  19q13.42
• Discovery year
  2005-07-15
• Entrez gene record
  574481
• RefSeq identity
  • NR_030203
• Classification
  • MicroRNA MIR515 family

Gene info

• Identity
  HGNC:33641
• Gene
  MIR509-2
• Long gene name
  microRNA 509-2
• Synonyms gene
  • MIRN509-2
• Synonyms
  • hsa-mir-509-2
• Locus
  Xq27.3
• Discovery year
  2007-10-24
• Entrez gene record
  100126301
• RefSeq identity
  • NR_030586
• Classification
  • MicroRNA MIR506 family

Gene info

• Identity
  HGNC:32091
• Gene
  MIR512-2
• Long gene name
  microRNA 512-2
• Synonyms gene
  • MIRN512-2
• Synonyms
  • hsa-mir-512-2
• Locus
  19q13.42
• Discovery year
  2005-07-15
• Entrez gene record
  574459
• RefSeq identity
  • NR_030181
• Classification
  • MicroRNA MIR506 family

Gene info

• Identity
  HGNC:31639
• Gene
  MIR7-2
• Long gene name
  microRNA 7-2
• Synonyms gene
  • MIRN7-2
• Synonyms
  • hsa-mir-7-2
• Locus
  15q26.1
• Discovery year
  2004-04-23
• Entrez gene record
  407044
• RefSeq identity
  • NR_029606
• Classification
  • MicroRNA MIR7 family

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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