Anti-ELK4/SAP-1a (Polyclonal), ALEXA Fluor 594

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• Catalog number
  GENTObs-13067R-A594
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• Size
  100 microliters

# #

• Type
  Conjugated Primary Antibody
• Conjugated with
  ALEXA FLUOR® 594
• Host organism
  Rabbit (Oryctolagus cuniculus)
• Target Protein Peptide
  ELK4/SAP-1a
• Specificity
  This antibody reacts specifically with ELK4/SAP-1a
• Modification
  No modification has been applied to this antibody
• Modification site
  None
• Clonality
  Polyclonal Antibody
• Clone
  Polyclonal Antibodies
• Concentration
  1ug per 1ul
• Subcellular locations
  N/A
• Antigen Source
  KLH conjugated synthetic peptide derived from human ELK4/SAP-1a
• Gene ID
  2005
• Swiss Prot
  N/A
• Applications
  IF(IHC-P)
• Applications with corresponding dilutions
  IF(IHC-P)(1:50-200)
• Cross reactive species
  Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)
• Cross Reactive Species details
  No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
• Background information
  Serum response factor (SRF) is a transcription factor that binds the serum response element (SRE), a sequence that mediates the transient response of many cellular genes to growth stimulation. SRF-binding sites are also constitutive promoter elements in many muscle-specific promoters. At the c-Fos SRE, formation of a ternary complex containing SRF and its accessory protein p62TCF appears to be important for signal transduction. Two related Ets domain proteins, Elk-1 and SRF accessory protein-1 (SAP-1), have DNA binding properties identical to that of p62TCF. Elk-1 and SAP-1 contain two homologous regions of which the two amino terminal regions, the Ets domain (box A) and the B box, mediate ternary complex formation with SRF. The third homologous region, the C box located toward the C-terminus of the proteins, contains conserved consensus phosphorylation sites for MAP kinases.
• Purification method
  Purified by Protein A.
• Storage
  Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
• Excitation emission
  590nm/617nm
• Synonyms
  Elk4; ELK4_HUMAN; ETS domain containing protein Elk4; ETS domain protein; ETS domain-containing protein Elk-4; SAP-1; SAP1; Serum response factor accessory protein 1; SRF accessory protein 1; TCF1.
• Also known as
  ELK4/SAP-1a Polyclonal Antibody
• Other name
  Anti-ELK4/SAP-1a Polyclonal
• Advisory
  Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
• Properties
  For facs or microscopy Alexa 1 conjugate.
• Conjugation
  Alexa Fluor, ALEXA FLUOR® 594
• Conjugated
  Alexa conjugate 1
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Group
  Polyclonals and antibodies
• About
  Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.

#

• Gene target
  ELK4/SAP-1a  
• Gene symbol
  GM2A, PTPRH, APCS, DLG1, DLG4, SH2D1A, DLG3, ELK4
• Short name
  Anti-ELK4/SAP-1a
• Technique
  Polyclonal, anti-, anti, antibody to, antibodies, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 594
• Alternative name
  ELK4/SAP-1a Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated
• Alternative technique
  polyclonals, antibodies

Gene info

• Identity
  HGNC:4367
• Gene
  GM2A
• Long gene name
  GM2 ganglioside activator
• Synonyms gene name
  • GM2 ganglioside activator protein
• Synonyms
  • SAP-3
• Synonyms name
  • cerebroside sulfate activator protein
  • sphingolipid activator protein 3
• Locus
  5q33.1
• Discovery year
  1986-01-01
• Entrez gene record
  2760
• Pubmed identfication
  • 115863
  • 1915857
• RefSeq identity
  • NM_000405
• VEGA ID
  OTTHUMG00000130124
• Locus Specific Databases
  • GM2A Locus Database

Gene info

• Identity
  HGNC:9672
• Gene
  PTPRH
• Long gene name
  protein tyrosine phosphatase receptor type H
• Synonyms
  • SAP-1
• Locus
  19q13.42
• Discovery year
  1994-09-14
• Entrez gene record
  5794
• Pubmed identfication
  • 8294459
• Classification
  • Protein tyrosine phosphatases receptor type
  • Fibronectin type III domain containing
• VEGA ID
  OTTHUMG00000180701

Gene info

• Identity
  HGNC:584
• Gene
  APCS
• Long gene name
  amyloid P component, serum
• Synonyms
  • SAP
  • PTX2
  • MGC88159
• Synonyms name
  • pentraxin-related
  • 9.5S alpha-1-glycoprotein
  • pentraxin-2
• Locus
  1q23.2
• Discovery year
  2001-06-22
• Entrez gene record
  325
• Pubmed identfication
  • 2987268
• RefSeq identity
  • NM_001639
• Classification
  • Short pentraxins
• VEGA ID
  OTTHUMG00000022741

Gene info

• Identity
  HGNC:2900
• Gene
  DLG1
• Long gene name
  discs large MAGUK scaffold protein 1
• Synonyms gene name
  • discs, large homolog 1 (Drosophila)
  • discs large homolog 1, scribble cell polarity complex component
• Synonyms
  • SAP97
  • SAP-97
  • hdlg
  • DLGH1
  • dJ1061C18.1.1
• Synonyms name
  • discs large homolog 1
  • presynaptic protein SAP97
  • synapse-associated protein 97
• GenBank acession
  • U13897
• Locus
  3q29
• Discovery year
  1995-05-04
• Entrez gene record
  1739
• Pubmed identfication
  • 7937897
  • 8825652
• RefSeq identity
  • NM_004087
• Classification
  • Membrane associated guanylate kinases
  • PDZ domain containing
  • MicroRNA protein coding host genes
  • Scribble complex
• VEGA ID
  OTTHUMG00000047972

Gene info

• Identity
  HGNC:2903
• Gene
  DLG4
• Long gene name
  discs large MAGUK scaffold protein 4
• Synonyms gene name
  • discs, large homolog 4 (Drosophila)
  • discs large homolog 4
• Synonyms
  • PSD-95
  • PSD95
  • SAP90
  • SAP-90
• GenBank acession
  • U83192
• Locus
  17p13.1
• Discovery year
  1995-11-07
• Entrez gene record
  1742
• Pubmed identfication
  • 9286702
• RefSeq identity
  • NM_001365
• Classification
  • Membrane associated guanylate kinases
  • PDZ domain containing
• VEGA ID
  OTTHUMG00000134327

Gene info

• Identity
  HGNC:10820
• Gene
  SH2D1A
• Long gene name
  SH2 domain containing 1A
• Synonyms gene
  • IMD5
  • LYP
• Synonyms gene name
  • lymphoproliferative syndrome
  • SH2 domain protein 1A
• Synonyms
  • XLP
  • MTCP1
  • DSHP
  • XLPD
  • EBVS
  • SAP
• Synonyms name
  • Duncan's disease
• GenBank acession
  • AL023657
• Locus
  Xq25
• Discovery year
  1989-06-30
• Entrez gene record
  4068
• Pubmed identfication
  • 9771704
  • 9774102
• RefSeq identity
  • NM_002351
• Classification
  • SH2 domain containing
• VEGA ID
  OTTHUMG00000022344
• Locus Specific Databases
  • SH2D1Abase: Mutation registry for X-linked lymphoproliferative syndrome (XLP)
  • LRG_106

Gene info

• Identity
  HGNC:2902
• Gene
  DLG3
• Long gene name
  discs large MAGUK scaffold protein 3
• Synonyms gene name
  • discs, large homolog 3 (neuroendocrine-dlg, Drosophila)
  • discs, large homolog 3 (Drosophila)
  • discs large homolog 3
• Synonyms
  • NE-Dlg
  • SAP102
  • SAP-102
  • NEDLG
  • KIAA1232
  • MRX90
  • PPP1R82
• Synonyms name
  • neuroendocrine-dlg
  • protein phosphatase 1, regulatory subunit 82
  • synapse associated protein 102
• GenBank acession
  • U49089
• Locus
  Xq13.1
• Discovery year
  1997-04-21
• Entrez gene record
  1741
• Pubmed identfication
  • 9598320
• RefSeq identity
  • NM_021120
• Classification
  • Membrane associated guanylate kinases
  • PDZ domain containing
  • Protein phosphatase 1 regulatory subunits
• VEGA ID
  OTTHUMG00000021778
• Locus Specific Databases
  • Global Variome shared LOVD

Gene info

• Identity
  HGNC:3326
• Gene
  ELK4
• Long gene name
  ETS transcription factor ELK4
• Synonyms gene name
  • ELK4, ETS-domain protein (SRF accessory protein 1)
• Synonyms
  • SAP1
• Synonyms name
  • SRF accessory protein 1
• GenBank acession
  • M85165
• Locus
  1q32.1
• Discovery year
  1994-12-23
• Entrez gene record
  2005
• Pubmed identfication
  • 7851904
  • 8575773
• RefSeq identity
  • NM_021795
• Classification
  • ETS transcription factor family
• VEGA ID
  OTTHUMG00000037221

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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