ACY-1215

Alternative_name

2-(diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide ; Rocilinostat; ACT-1215
Description

ACY-1215 is a potent, cell-permeable and selective inhibitor of histone deacetylase 6 (HDAC6) (IC₅₀ = 5 nM). ACY-1215 is 12-, 10-, 11 and 21-fold less active against HDAC1, HDAC2, HDAC3 and HDAC8, respectively. It displays minimal activities (IC₅₀ > 1 µM) against HDAC4, HDAC5, HDAC7, HDAC9, HDAC11, Sirtuin1, and Sirtuin2. In combination with Tubastatin (Cat. No. 1724), it improves cognition in Alzheimer’s Disease (AD) transgenic mice.
CAS Number

1316214-52-4
Structure Available

Y
Salt Form

No
Molecular Formula

C₂₄H₂₇N₅O₃
Molecular Weight

433.5
Cell Permeable

Yes
Purity

>98% by HPLC
Solubilities

DMSO (>75 mg/ml)
Handling

Protect from air and light
Tag Line

A potent HDAC6 inhibitor
Storage Condition

-20 ̊C
Shipping Condition

Gel pack
Shelf Life

36 months
PubChem CID

53340666
PubChem CID Link
SMILES

C1=CC=C(C=C1)N(C2=CC=CC=C2)C3=NC=C(C=N3)C(=O)NCCCCCCC(=O)NO
InChi

InChI=1S/C24H27N5O3/c30-22(28-32)15-9-1-2-10-16-25-23(31)19-17-26-24(27-18-19)29(20-11-5-3-6-12-20)21-13-7-4-8-14-21/h3-8,11-14,17-18,32H,1-2,9-10,15-16H2,(H,25,31)(H,28,30)
InChi Key

QGZYDVAGYRLSKP-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes