UNC 1215

Alternative_name

(2-(Phenylamino)-1,4-phenylene)bis((4-(pyrrolidin-1-yl)piperidin-1-yl)methanone
Description

Cell-permeable. A potent and selective chemical probe for the methyllysine (Kme) reading function of L3MBTL3, a member of the malignant brain tumor (MBT) family of chromatin-interacting transcriptional repressors. It binds L3MBTL3 with a Kd value of 120 nM (IC₅₀ = 40 nM), competitively displacing mono- or dimethyl-lysine containing peptides. UNC1215 is > 50-fold selective toward L3MBTL3 than other members of the human MBT family and demonstrates selectivity against more than 200 other Kme reader domains examined.
CAS Number

1415800-43-9
Structure Available

Yes
Salt Form

No
Molecular Formula

C₃₂H₄₃N₅O₂
Molecular Weight

529.72
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (50 mM)
Handling

Protect from light and moisture
Tag Line

A potent L3MBTL3 domain inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

24 months
PubChem CID

57339144
PubChem CID Link
SMILES

C1CCN(C1)C2CCN(CC2)C(=O)C3=CC(=C(C=C3)C(=O)N4CCC(CC4)N5CCCC5)NC6=CC=CC=C6
InChi

InChI=1S/C32H43N5O2/c38-31(36-20-12-27(13-21-36)34-16-4-5-17-34)25-10-11-29(30(24-25)33-26-8-2-1-3-9-26)32(39)37-22-14-28(15-23-37)35-18-6-7-19-35/h1-3,8-11,24,27-28,33H,4-7,12-23H2
InChi Key

PQOOIERVZAXHBP-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:1426
Gene

CADPS
Long gene name

calcium dependent secretion activator
Synonyms gene name
- Ca++-dependent secretion activator
- Ca2+ dependent secretion activator
Synonyms
- CAPS
- KIAA1121
- CAPS1
- UNC-31
GenBank acession
- U36448
Locus

3p14.2
Discovery year

1999-07-21
Entrez gene record

8618
Pubmed identfication
- 1516133
RefSeq identity
Classification
- Pleckstrin homology domain containing
VEGA ID

OTTHUMG00000158651

Identity

HGNC:26582
Gene

UNC80
Long gene name

unc-80 homolog, NALCN channel complex subunit
Synonyms gene
- C2orf21
Synonyms gene name
- chromosome 2 open reading frame 21
- unc-80 homolog (C. elegans)
Synonyms
- FLJ33496
- KIAA1843
- UNC-80
GenBank acession
- AK090815
Locus

2q34
Discovery year

2004-01-20
Entrez gene record

285175
Pubmed identfication
RefSeq identity
- NM_182587
VEGA ID

OTTHUMG00000132963

Identity

HGNC:16097
Gene

LAMP5
Long gene name

lysosomal associated membrane protein family member 5
Synonyms gene
- C20orf103
Synonyms gene name
- chromosome 20 open reading frame 103
- lysosomal-associated membrane protein family, member 5
Synonyms
Synonyms name
- brain and dendritic cell associated LAMP
GenBank acession
- AL121740
Locus

20p12.2
Discovery year

2001-07-17
Entrez gene record

24141
Pubmed identfication
- 11780052
- 21642595
RefSeq identity
- NM_012261
Classification
- Lysosome associated membrane proteins
VEGA ID

OTTHUMG00000031851