Recombinant Human CD32b / FCGR2B Protein (His tag) 100µg

• Catalog number
  PKSH031727-100µg
• Price
  Please ask
• Size
  100µg

• Synonym
  CD32;CD32B;Fc gamma RIIB;FCGR2
• Activity
  Measured by its binding ability in a functional ELISA.Immobilized human sCD32b-His (CHO) at 10 μg/ml (100 μl/well) can bind biotinylated human IgG1, The EC50 of biotinylated human IgG1 is 0.18-0.42 μg/ml.
• Sequence
  Ala46-Pro217
• Fusion tag
  C-His
• Accession
  P31994-1
• Expressed Host
  CHO Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  > 97 % as determined by SDS-PAGE
• Endotoxin
  < 1.0 EU per μg of the protein as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  20.8 kDa
• AP Mol Mass
  29 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Reconstitution
  Please refer to it for detailed information.
• Background
  The Lutheran (Lu) blood group and basal cell adhesion molecule (BCAM) antigens are both carried by 2 glycoprotein isoforms of the immunoglobulin superfamily representing receptors for the laminin alpha(5) chain. It is a transmembrane receptor with five immunoglobulin-like domains in its extracellular region, and is therefore classified as a member of the immunoglobulin (Ig) gene family. In addition to red blood cells, Lu/BCAM proteins are expressed in endothelial cells of vascular capillaries and in epithelial cells of several tissues. BCAM/LU has a wide tissue distribution with a predominant expression in the basal layer of the epithelium and the endothelium of blood vessel walls. As designated as CD239 recently, BCAM and LU share a significant sequence similarity with the CD146 (MUC18) and CD166, and themselves are adhesion molecules that bind laminin with high affinity. Laminins are found in all basement membranes and are involved in cell differentiation, adhesion, migration, and proliferation. BCAM is upregulated following malignant transformation of some cell types in vivo and in vitro, thus being a candidate molecule involved in tumor progression. In addition, BCAM interacts with integrin in sickle red cells, and thus may potentially play a role in vaso-occlusive episodes.
• Product URL
• PDF URL
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CD32b   FCGR2B   Protein   His   tag   100µg  
• Gene symbol
  FCGR2B
• Short name
  Recombinant CD32b / FCGR2B Protein (His tag) 100µg
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens CD32b / fragment c fragment on Immunoglobulin G, low affinity IIb, receptor (CD32) Protein (histidine detection labelled) 100µg
• Alternative technique
  rec
• Alternative to gene target
  Fc fragment of IgG, low affinity IIb, receptor (CD32), CD32 and CD32B and FCG2 and FCGR2 and IGFR2, FCGR2B and IDBG-104308 and ENSG00000072694 and 2213, IgG binding, Plasma membranes

Gene info

• Identity
  HGNC:3618
• Gene
  FCGR2B
• Long gene name
  Fc gamma receptor IIb
• Synonyms gene
  • FCG2
  • FCGR2
• Synonyms gene name
  • Fc fragment of IgG, low affinity IIb, receptor for (CD32)
  • Fc fragment of IgG, low affinity IIb, receptor (CD32)
  • Fc fragment of IgG receptor IIb
• Synonyms
  • CD32
  • CD32B
  • FcgammaRIIb
  • FcGRIIB
• GenBank acession
  • BC031992
• Locus
  1q23.3
• Discovery year
  1991-08-21
• Entrez gene record
  2213
• Pubmed identfication
  • 2139735
  • 19309690
• RefSeq identity
  • NM_004001
• Classification
  • CD molecules
  • Immunoglobulin like domain containing
• VEGA ID
  OTTHUMG00000034470

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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