RAGE, human recombinant
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Catalog number4271-50
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PricePlease ask
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Size50 ug
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SynonymsReceptor for advanced glycosylation end products
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Alternative_namesAdvanced glycosylation end product-specific receptor, Receptor for advanced glycosylation end products, AGER
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DescriptionTransmembrane receptor of the immunoglobulin super family
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RecombinantYes
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SourceHuman cells
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Purity by SDS PAGE≥95%
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AssaySDS-PAGE
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Purity≥95%
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Molecular Weight~35 kDa
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Storage Temp-20°C
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ShippingGel pack
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Shelf Life12 months
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AppearanceLyophilized protein
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Physical form descriptionLyophilized from a 0.2 um filtered solution of 20 mM PB and 150 mM NaCl, pH7.2.
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Reconstitution InstructionsDissolve in 1x PBS (It is not recommended to reconstitute to a final concentration less than 100 ug/ml.). After adding 1x PBS, let the tube stand at room temperature for 3 minutes to allow lyophilized protein to dissolve. Mix the solution by inverting the tube 5 times. Centrifuge to pool sample.
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Background InformationAdvanced glycosylation end product-specific receptor, also known as receptor for advanced glycosylation end products, AGER and RAGE, belongs to the immunoglobulin superfamily of cell surface molecules. It lies within the major histocompatibility complex (MHC) class III region on chromosome 6. Besides AGEs, AGER is also able to bind other ligands which is thought to result in pro-inflammatory gene activation. It is known that AGER serves as a mediator of both acute and chronic vascular inflammation in certain conditions such as atherosclerosis and in particular as a complication of diabetes. Furthermore, it plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes.
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Amino acid sequenceRecombinant human AGER/RAGE produced by transfected human cell is a secreted protein with sequence (Ala23-Ala344) of human AGER/RAGE (Uniprot Entry: Q15109) fused with a poly-histidine tag at the C-terminus.
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HandlingCentrifuge the vial prior to opening.
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UsageFor Research Use Only! Not to be used in humans
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PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional sourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolAGER, MOK
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Short nameRAGE, recombinant
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TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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SpeciesHuman, Humans
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Alternative nameRAGE, H. sapiens Rec.
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Alternative techniquerec
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Gene info
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Identity
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Gene
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Long gene nameadvanced glycosylation end-product specific receptor
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1994-10-17
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Scavenger receptors
- C2-set domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameMOK protein kinase
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Synonyms gene
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Synonyms gene name
- renal tumor antigen
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Synonyms
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GenBank acession
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Locus
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Discovery year1995-05-10
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Entrez gene record
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Pubmed identfication
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VEGA ID
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data