- Catalog numberF43706-0.4ML
- Product nameRage Antibody
- Size0.4 ml
- PriceAsk For Price
- Short nameAnti-Rage
- CategoryAntibody
- ConcentrationIn 1X PBS, pH 7.4, with 0.09% sodium azide
- FormAntigen affinity purified
- ConjugationUnconjugated
- ClonePolyclonal antibody
- Recognised antigenRage
- Host animalRabbit (Oryctolagus cuniculus)
- ClonalityPolyclonal (rabbit origin)
- IsotypeRabbit Ig
- Species reactivityHuman (Homo sapiens), Mouse (Mus musculus) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
- Tested applicationsWB, ELISA
- Recommended dilutionsWestern blot: 1:1000
- NotesTitration of the Rage antibody may be required due to differences in protocols and secondary/substrate sensitivity.
- Intented useThis Rage antibodyis to be used only for research purposes and not for diagnostics..
- UniprotQ9WVS4
- PurityAntigen affinity
- DescriptionRAGE, the 'receptor for advanced glycation endproducts' is a transmembrane receptor of the immunoglobulin super family. The interaction between RAGE and its ligands, AGE and HMGB1, is thought to result in pro-inflammatory gene activation. Due to an enhanced level of RAGE ligands in diabetes or other chronic disorders, this receptor is hypothesised to have a causative effect in a range of inflammatory diseases such as diabetic complications, Alzheimer's disease and even some tumors. [Wiki]
- ImmunogenA portion of amino acids 76-104 from the mouse protein was used as the immunogen for this Rage antibody.
- StorageAliquot the Rage antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
- Gene targetRage
- Identity:HGNC:9833
- Gene:MOK
- Long gene name:MOK protein kinase
- Synonyms gene name:renal tumor antigen
- Synonyms:RAGE1STK30
- Discovery year:1995-05-10
- Entrez gene record:5891
- Pubmed identification:8781117, 10421840
- VEGA ID:OTTHUMG00000164896
- Identity:HGNC:320
- Gene:AGER
- Long gene name:advanced glycosylation end-product specific receptor
- Synonyms:RAGESCARJ1sRAGE
- Discovery year:1994-10-17
- Entrez gene record:177
- Pubmed identification:7713518
- RefSeq identity:NM_001136
- Classification:Scavenger receptors, C2-set domain containing
- VEGA ID:OTTHUMG00000031120
- Gene symbolMOK, AGER
- isotype filter
- Rabbit Ig
- technique filter
- Antibody
- TechniqueAntibody, antibodies against human proteins, antibodies for
- Alternative techniqueantibodies