anti-ATR Antibody
#
-
Catalog number3119
-
Price:
-
Size0.02 mg, 0.1 mg
-
-
Gene infoATR Antibody: The Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8). This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin. Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF). This complex is then endocytosed by the cell; acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis.
-
Gene namesATR Antibody: ATR, GAPO, TEM8, ATR, Anthrax toxin receptor 1, Tumor endothelial marker 8
-
Antibodie s labelunlabelled serum
-
PurityATR Antibody is Ion exchange chromatography purified.
-
Ab raised inRabbit
-
TypePolyclonal
-
ImmunoglobulinIgG
-
Spicific toATR antibody will recognize only the largest isoform.
-
AntigenATR antibody was made against a peptide corresponding to 13 amino acids near the C-terminus of human ATR.
-
Immuno applicationELISA, Western Blot, immuno-cyto-chemistry, immuno fluorescence
-
Antibody adviceATR antibody can be used for detection of ATR by Western blot at 0.5 to 2 ug/mL. Antibody can also be used for immunocytochemistry starting at 2 ug/mL. For immunofluorescence start at 10 ug/mL.
-
Suspention pH azideATR Antibody is supplied in PBS containing 0.02% sodium azide.
-
Keep atATR antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
-
Works withHuman, Mouse, Rat
-
Omim nr16933551
-
Ncbi nrNP_444262
-
Vial with antibodyin solution
-
Quantity per ml1 mg/mL
-
NCBI GENE nr84168
-
GENE symbolANTXR1
-
Antigene nameanthrax toxin receptor 1
-
SourceHomo sapiens
-
Protein nrQ9H6X2
-
DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
-
PropertiesIf you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
French translationanticorps
-
Gene target
-
Gene symbolANTXR1, SERPINA2, ATR
-
Short nameanti-ATR Antibody
-
TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
-
Alternative nameAntibody toATR (antibody to-)
-
Alternative techniqueantibodies
-
Alternative to gene targetataxia telangiectasia and Rad3 related, FCTCS and FRP1 and MEC1 and SCKL and SCKL1, ATR and IDBG-59521 and ENSG00000175054 and 545, transferase activity, nuclei, Atr and IDBG-191646 and ENSMUSG00000032409 and 245000, ATR and IDBG-638174 and ENSBTAG00000011529 and 504869
-
Gene info
-
Identity
-
Gene
-
Long gene nameANTXR cell adhesion molecule 1
-
Synonyms gene name
- anthrax toxin receptor 1
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2003-08-27
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- MicroRNA protein coding host genes
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameserpin family A member 2 (gene/pseudogene)
-
Synonyms gene
-
Synonyms gene name
- serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2
- serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2, pseudogene
- serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene)
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2001-06-22
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Serpin peptidase inhibitors
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameATR serine/threonine kinase
-
Synonyms gene name
- ataxia telangiectasia and Rad3 related
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1998-04-06
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Armadillo like helical domain containing
-
VEGA ID
-
Locus Specific Databases
MeSH Data
-
Name
-
ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data