Rebastinib (DCC-2036)

• Catalog number
  B1619-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  DCC-2036; DCC-2036; DCC2036; Bcr-Abl inhibitor; Bcr-abl inhibitor; 4-[4-[(5-tert-butyl-2-quinolin-6-ylpyrazol-3-yl)carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
• Description
  DCC-2036 (Rebastinib) is an inhibitor of Bcr-Abl with IC50 of 0.8 nM and 4 nM for Abl1(WT) and Abl1(T315I), respectively.
• CAS Number
  1020172-07-9
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₃₀H₂₈FN₇O₃
• Molecular Weight
  553.59
• Cell Permeable
  Yes
• Purity
  >98%
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A Bcr-Abl inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD19443646
• PubChem CID
  25066467
• PubChem CID Link
• SMILES
  CC(C)(C)C1=NN(C(=C1)NC(=O)NC2=C(C=C(C=C2)OC3=CC(=NC=C3)C(=O)NC)F)C4=CC5=C(C=C4)N=CC=C5
• InChi
  1S/C30H28FN7O3/c1-30(2,3)26-17-27(38(37-26)19-7-9-23-18(14-19)6-5-12-33-23)36-29(40)35-24-10-8-20(15-22(24)31)41-21-11-13-34-25(16-21)28(39)32-4/h5-17H,1-4H3,(H,32,39)(H2,35,36,40)
• InChi Key
  WVXNSAVVKYZVOE-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Rebastinib   DCC-2036  
• Gene symbol
  DCC
• Short name
  Rebastinib (DCC-2036)
• Alternative name
  Rebastinib (deleted in colorectal carcinoma-2036)
• Alternative to gene target
  deleted in colorectal carcinoma, CRC18 and CRCR1 and IGDCC1 and MRMV1 and NTN1R1, DCC and IDBG-3511 and ENSG00000187323 and 1630, identical protein binding, Plasma membranes, Dcc and IDBG-157336 and ENSMUSG00000060534 and 13176

Gene info

• Identity
  HGNC:2701
• Gene
  DCC
• Long gene name
  DCC netrin 1 receptor
• Synonyms gene name
  • deleted in colorectal carcinoma
• Synonyms
  • IGDCC1
  • NTN1R1
• Synonyms name
  • immunoglobulin superfamily, DCC subclass, member 1
• GenBank acession
  • X76132
• Locus
  18q21.2
• Discovery year
  1990-05-25
• Entrez gene record
  1630
• Pubmed identfication
  • 2294591
  • 24400119
• RefSeq identity
  • NM_005215
• Classification
  • Fibronectin type III domain containing
  • MicroRNA protein coding host genes
  • I-set domain containing
• VEGA ID
  OTTHUMG00000132698
• Locus Specific Databases
  • LRG_1107

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