Human CellExp™ VSIG4, human recombinant

• Catalog number
  P1018-10
• Price
  Please ask
• Size
  10 µg

• Synonyms
  V-set and immunoglobulin domain containing 4; Z39Ig; CRIg
• Alternative_names
  V-set and immunoglobulin domain containing 4; Z39Ig; CRIg
• Description
  V-set and immunoglobulin domain-containing protein 4
• Recombinant
  Yes
• Source
  HEK 293 cells
• Purity by SDS PAGE
  ≥ 98%
• Assay
  SDS-PAGE
• Endotoxin Level
  < 0.06 EU/mg
• Molecular Weight
  68 kDa
• Storage Temp
  -20°C
• Shipping
  Gel pack
• Shelf Life
  12 months
• Appearance
  Lyophilized
• Physical form description
  Lyophilized from 0.2um-filtered solution in PBS.
• Reconstitution Instructions
  Reconstitute in 1X PBS to the desired protein concentration.
• Background Information
  VSIG4 (V-set and immunoglobulin domain containing 4), as known as complement receptor of the immunoglobulin superfamily (CRIg) and Z39Ig. It is a B7 family-related protein and an Ig superfamily member. In contrast to the B7 family members which contain two IgG domains, VSIG4 contains one complete V-type I g domain and a truncated C-type I g domain. VSIG4 is exclusively expressed on tissue resident macrophages and binds to multimers of C3b and iC3b that are covalently attached to particle surfaces. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CellExp™   VSIG4  
• Gene symbol
  VSIG4
• Short name
  CellExp™ VSIG4, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Humans
• Alternative name
  H. sapiens CellExp™ V-set and immunoglobulin domain containing 4, H. sapiens Rec.
• Alternative technique
  rec
• Alternative to gene target
  V-set and immunoglobulin domain containing 4, CRIg and Z39IG, VSIG4 and IDBG-73541 and ENSG00000155659 and 11326, protein binding, Plasma membranes, Vsig4 and IDBG-160903 and ENSMUSG00000044206 and 278180, VSIG4 and IDBG-637672 and ENSBTAG00000015769 and 614262

Gene info

• Identity
  HGNC:17032
• Gene
  VSIG4
• Long gene name
  V-set and immunoglobulin domain containing 4
• Synonyms
  • Z39IG
  • CRIg
• Synonyms name
  • complement receptor of the immunoglobulin superfamily
• GenBank acession
  • AJ132502
• Locus
  Xq12
• Discovery year
  2004-09-10
• Entrez gene record
  11326
• Pubmed identfication
  • 11004523
  • 17016555
  • 17016562
• RefSeq identity
  • NM_007268
• Classification
  • Complement system regulators and receptors
  • V-set domain containing
• VEGA ID
  OTTHUMG00000021727
• Locus Specific Databases
  • Global Variome shared LOVD

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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