PathwayReady™ JAK/STAT Signaling Inhibitor Panel
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Catalog numberK864-8
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PricePlease ask
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Size8 inhibitors
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Alternative_nameJAK/STAT Signaling Inhibitor Panel, PathwayReady™
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DescriptionA convenient set consisting of eight inhibitors useful for studying JAK/STAT signaling pathway. The inhibitors are: 5 mg of AG 490 (Cat. No. 1570-5), 5 mg of CP-690550 (Cat. No. 1622-5), 500 µg of Lestaurtinib (Cat. No. 1805-500), 5 mg of LLL12 (Cat. No. 1792-5), 50 mg of Pimozide (Cat. No. 1887-50), 5 mg of Stat3 Inhibitor, S3I-201 (Cat. No. 1775-5), 5 mg of Stat3 Inhibitor, Celll-Permeable (Cat. No. 1778-1), and 5 mg of WP1066 (Cat. No. 1809-5).
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CAS NumberSee under the individual product
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Structure AvailableSee under the individual product
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Salt FormNo
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Molecular FormulaSee under the individual product
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Molecular WeightSee under the individual product
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Cell PermeableYes
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Purity≥95% by HPLC
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SolubilitiesSee under the individual product
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HandlingProtect from air, light and moisture
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Tag LineA JAK/STAT pathway signaling inhibitors set
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life24 months
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SMILESN/A
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InChiN/A
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InChi KeyN/A
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MSDS AvailableYes
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme. Cell nucleus signaling proteins and molecules are part of a complex system of communication that governs basic cellular activities and coordinates cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity as well as normal tissue homeostasis. Errors in cellular information processing are responsible for diseases such as cancer, autoimmunity, and diabetes. By understanding cell signaling, diseases may be treated effectively and, theoretically, artificial tissues may be created. STAT proteins are phosphorylated by receptor related kinases and for homo or hetero dimers. JAK-STAT pathways are signaling to the nucleus of the cell.
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Gene target
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Gene symbolJAK3, STAT6, SOAT1
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Short namePathwayReady™ JAK/STAT Signaling Inhibitor Panel
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Alternative namePathwayReady™ JAK/Signal transducer and activation on transcription Signaling suppressor Panel
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Tissuepanel
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Gene info
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Identity
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Gene
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Long gene nameJanus kinase 3
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1994-12-19
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Jak family tyrosine kinases
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namesignal transducer and activator of transcription 6
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Synonyms gene name
- signal transducer and activator of transcription 6, interleukin-4 induced
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Synonyms
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GenBank acession
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Locus
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Discovery year1995-11-09
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- SH2 domain containing
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namesterol O-acyltransferase 1
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Synonyms gene
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Synonyms gene name
- sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1998-11-04
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Recording of pertinent information concerning patient's illness or illnesses.
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Tree numbers
- E05.318.308.940.968
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Qualifiersclassification, economics, legislation & jurisprudence, standards, statistics & numerical data