L-JNK Peptide Inhibitor I

• Catalog number
  7011-50
• Price
  Please ask
• Size
  50 ul

• Description
  L-JNK Peptide Inhibitor competitively blocks the interaction between JNK and c-Jun, thereby inhibiting the signaling events downstream of JNK, like c-Jun, ATF-2 and ELK1 phosphorylation. To convert JIP-1/IB-1 into cell permeable inhibitors of JNK (JNKI1) the minimal 20 amino acids inhibitory sequence of JIP-1/IB1 was covalently linked to the 10 amino acids recognized by TAT transporter. The L-JNKI1 is a potent inhibitor that is specific for JNK and can be used for in vitro applications.
• Structure Available
  No
• Peptide sequence
  GRKKRRQRRR-PP-RPKRPTTLNLFPQVPRSQD-amide
• Salt Form
  No
• Molecular Formula
  C₁₆₄H₂₈₆N₆₆O₄₀
• Molecular Weight
  3822.5
• Cell Permeable
  Yes
• Purity
  ≥97% by HPLC
• Handling
  Protect from air and light
• Tag Line
  A cell-permeable JNK inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  Gel Pack
• Shelf Life
  12 months
• MDL Number
  MFCD12912420
• SMILES
  N/A
• InChi
  N/A
• InChi Key
  N/A
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme. Peptides short amino acid chains or epitopes or blocking antagonists. The shortest peptides are dipeptides, consisting of 2 amino acids joined by a single peptide bond, followed by tripeptides, tetra peptides, ... till polypeptides that are long, continuous, and unbranched synthetic peptide chains. These biological oligomers and polymers can be Solid-phase peptide synthesis (SPPS), or in continue produced for custom peptide synthesis projects. The High-efficiency solid phase peptide synthesis (HE-SPPS) is give very low production costs.

• Gene target
  L-JNK   Peptide   Inhibitor  
• Gene symbol
  MAPK8, CPT1A, POM121L2, L3MBTL2, CLDN10, RPL32P1, FABP1, COX7A2, NFIA, MAS1L
• Short name
  L-JNK Peptide Inhibitor I
• Technique
  peptide, peptides
• Alternative name
  L-JNK short protein sequence suppressor I
• Alternative technique
  peptides

Gene info

• Identity
  HGNC:6881
• Gene
  MAPK8
• Long gene name
  mitogen-activated protein kinase 8
• Synonyms gene
  • PRKM8
• Synonyms
  • JNK
  • JNK1
  • SAPK1
• Synonyms name
  • JUN N-terminal kinase
• GenBank acession
  • L26318
• Locus
  10q11.22
• Discovery year
  1998-04-28
• Entrez gene record
  5599
• Pubmed identfication
  • 8137421
  • 8654373
• Classification
  • Mitogen-activated protein kinases
• VEGA ID
  OTTHUMG00000018172

Gene info

• Identity
  HGNC:2328
• Gene
  CPT1A
• Long gene name
  carnitine palmitoyltransferase 1A
• Synonyms gene
  • CPT1
• Synonyms gene name
  • carnitine palmitoyltransferase 1A (liver)
• Synonyms
  • CPT1-L
  • L-CPT1
• GenBank acession
  • L39211
• Locus
  11q13.3
• Discovery year
  1995-05-30
• Entrez gene record
  1374
• Pubmed identfication
  • 7892212
  • 9070950
• RefSeq identity
  • NM_001876
• VEGA ID
  OTTHUMG00000167892

Gene info

• Identity
  HGNC:13973
• Gene
  POM121L2
• Long gene name
  POM121 transmembrane nucleoporin like 2
• Synonyms gene name
  • POM121 membrane glycoprotein-like 2 (rat)
  • POM121 membrane glycoprotein-like 2
  • POM121 transmembrane nucleoporin-like 2
• Synonyms
  • POM121-L
• GenBank acession
  • AL021808
• Locus
  6p22.1
• Discovery year
  2001-07-20
• Entrez gene record
  94026
• RefSeq identity
  • NM_033482
• VEGA ID
  OTTHUMG00000014475

Gene info

• Identity
  HGNC:18594
• Gene
  L3MBTL2
• Long gene name
  L3MBTL histone methyl-lysine binding protein 2
• Synonyms gene name
  • l(3)mbt-like 2 (Drosophila)
  • L3MBTL2, polycomb repressive complex 1 subunit
• Synonyms
  • H-l(3)mbt-l
  • DKFZP761I141
  • dJ756G23.3
• GenBank acession
  • AJ305226
• Locus
  22q13.2
• Discovery year
  2002-04-29
• Entrez gene record
  83746
• Pubmed identfication
  • 11682070
  • 21596310
• RefSeq identity
  • NM_031488
• Classification
  • MBT domain containing
• VEGA ID
  OTTHUMG00000150942

Gene info

• Identity
  HGNC:2033
• Gene
  CLDN10
• Long gene name
  claudin 10
• Synonyms
  • OSP-L
  • CPETRL3
• GenBank acession
  • U89916
• Locus
  13q32.1
• Discovery year
  1999-01-22
• Entrez gene record
  9071
• Pubmed identfication
  • 18025272
• RefSeq identity
  • NM_006984
• Classification
  • Claudins
• VEGA ID
  OTTHUMG00000017217

Gene info

• Identity
  HGNC:10339
• Gene
  RPL32P1
• Long gene name
  ribosomal protein L32 pseudogene 1
• Synonyms gene
  • RPL32P
• Synonyms gene name
  • ribosomal protein L32 pseudogene
• Synonyms
  • RPL32-L
• GenBank acession
  • X02228
• Locus
  6p21.32
• Discovery year
  2009-03-01
• Entrez gene record
  6163
• Pubmed identfication
  • 3866218
  • 19123937
• RefSeq identity
  • NG_000869
• VEGA ID
  OTTHUMG00000031191

Gene info

• Identity
  HGNC:3555
• Gene
  FABP1
• Long gene name
  fatty acid binding protein 1
• Synonyms gene name
  • fatty acid binding protein 1, liver
• Synonyms
  • L-FABP
• GenBank acession
  • M10617
• Locus
  2p11.2
• Discovery year
  2001-06-22
• Entrez gene record
  2168
• Pubmed identfication
  • 3012800
  • 17698986
• RefSeq identity
  • NM_001443
• Classification
  • Fatty acid binding protein family
• VEGA ID
  OTTHUMG00000130312

Gene info

• Identity
  HGNC:2288
• Gene
  COX7A2
• Long gene name
  cytochrome c oxidase subunit 7A2
• Synonyms gene name
  • cytochrome c oxidase subunit VIIa polypeptide 2 (liver)
• Synonyms
  • COXVIIa-L
  • COX7AL
• GenBank acession
  • X15822
• Locus
  6q14.1
• Discovery year
  1992-11-25
• Entrez gene record
  1347
• Pubmed identfication
  • 1327965
  • 9202412
• RefSeq identity
  • NM_001865
• Classification
  • Mitochondrial complex IV: cytochrome c oxidase subunits
• VEGA ID
  OTTHUMG00000015049

Gene info

• Identity
  HGNC:7784
• Gene
  NFIA
• Long gene name
  nuclear factor I A
• Synonyms gene name
  • nuclear factor I/A
• Synonyms
  • NFI-L
  • KIAA1439
• GenBank acession
  • U07809
• Locus
  1p31.3
• Discovery year
  1995-03-09
• Entrez gene record
  4774
• Pubmed identfication
  • 7590749
• RefSeq identity
  • NM_005595
• Classification
  • Nuclear factor I family
• VEGA ID
  OTTHUMG00000008618

Gene info

• Identity
  HGNC:13961
• Gene
  MAS1L
• Long gene name
  MAS1 proto-oncogene like, G protein-coupled receptor
• Synonyms gene name
  • MAS1 oncogene-like
• Synonyms
  • MAS-L
  • MRG
  • dJ994E9.2
• GenBank acession
  • S78653
• Locus
  6p22.1
• Discovery year
  2002-11-18
• Entrez gene record
  116511
• RefSeq identity
  • NM_052967
• Classification
  • G protein-coupled receptors, Class A orphans
• VEGA ID
  OTTHUMG00000031089

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